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Development of nanostructured dressings containing antimicrobial agents aiming at tissue engineering applications in cattle

Grant number: 19/26622-4
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2021
Effective date (End): December 31, 2024
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Luiz Henrique Capparelli Mattoso
Grantee:Juliana Farinassi Mendes
Host Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Associated research grant:18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis, AP.TEM


Innovative materials from abundant renewable resources are becoming an important area of research today. The development of polymeric nanofiber membranes based mainly on underutilized natural resources is, however, scarce, making this topic worthy of further exploration. Pereskia aculeata Miller (ora-pro-nobis) has great potential for extracting bioactive compounds with excellent nutraceutical functions and may slow down inflammatory processes and skin recovery, ensuring added value to this material. The addition of peppermint essential oil and antibiotic will be used to increase antimicrobial, antioxidant action and compare their efficiencies. Thus, the main objective of this project is to develop processing conditions for obtaining antimicrobial, antioxidant and healing nanofiber membranes from natural sources, and to give the films properties for applications in the care of wound infections in livestock. They will be used as the pure poly (lactic acid) polymer (PLA) and PLA / arabionogalactano blends extracted from ora-pro-nobis. The nanofiber membranes will be obtained by the airbrush or airbrushing method. Detailed studies of the raw materials and the membranes will be performed, seeking optimization of the parameters for the extraction and incorporation of bioactive compounds in the polymer matrix and obtaining promising properties of the membranes. The membranes will also be evaluated for their application through in vitro and in vivo studies in order to study the efficiency in healing and tissue regeneration.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NORCINO, LAIS BRUNO; MENDES, JULIANA FARINASSI; FIGUEIREDO, JAYNE DE ABREU; OLIVEIRA, NATALIA LEITE; BOTREL, DIEGO ALVARENGA; CAPPARELLI MATTOSO, LUIZ HENRIQUE. Development of alginate/pectin microcapsules by a dual process combining emulsification and ultrasonic gelation for encapsulation and controlled release of anthocyanins from grapes (Vitis labrusca L.). Food Chemistry, v. 391, p. 7-pg., . (19/26622-4)
FREITAS, JOHN A. M.; MENDONCA, GIOVANA M. N.; SANTOS, LETICIA B.; ALONSO, JOVAN D.; MENDES, JULIANA F.; BARUD, HERNANE S.; AZEREDO, HENRIETTE M. C.. Bacterial Cellulose/Tomato Puree Edible Films as Moisture Barrier Structures in Multicomponent Foods. FOODS, v. 11, n. 15, p. 11-pg., . (19/26622-4)
MENDES, JULIANA FARINASSI; NORCINO, LAIS BRUNO; CORREA, THAILA QUATRINI; BARBOSA, TALITA VILLA; PASCHOALIN, RAFAELLA T.; MATTOSO, LUIZ HENRIQUE CAPPARELLI. Obtaining poly (lactic acid) nanofibers encapsulated with peppermint essential oil as potential packaging via solution-blow-spinning. International Journal of Biological Macromolecules, v. 230, p. 13-pg., . (17/18725-2, 19/26622-4)
MENDES, JULIANA FARINASSI; NORCINO, LAIS BRUNO; MANRICH, ANNY; DE OLIVERIA, TIAGO JOSE PIRES; MENDES, RAFAEL FARINASSI; MATTOSO, LUIZ HENRIQUE CAPPARELLI. Pectin-based color indicator films incorporated with spray-dried Hibiscus extract microparticles. Food Research International, v. 162, p. 15-pg., . (19/26622-4)

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