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Identification of prognostic variables from the cardiopulmonary exercise test to stratify Heart Failure severity

Grant number: 20/13465-5
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): November 30, 2021
Effective date (End): March 29, 2022
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal researcher:Audrey Borghi e Silva
Grantee:Cássia da Luz Goulart
Supervisor abroad: Agostoni Piergiuseppe
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Università degli Studi di Milano, Italy  
Associated to the scholarship:18/03233-0 - Study of cardiorespiratory interaction and the supply of peripheral and cerebral oxygen as modulators of exercise capacity during bilevel application in the coexistence of COPD-CHF, BP.DD

Abstract

Heart Failure (HF) patients have shown mark intolerance towards exercise, which is related to the severity of the disease. Therefore, it is of utmost importance to perform tests of maximum exercise, since they can measure and identify possible cutoff points to stratify HF gravity. Aim: To analyze all the variables derived from the cardiopulmonary exercise testing (CPET), but prioritize Oxygen uptake (VO2)/ workload (WR), ventilation intercept (VEint), Circulatory Power (CP) and Ventilatory Power (VP); to evaluate the behavior of these variables in the different classifications of HF, and draw prognosis and mortality cut points in these patients, if proven feasible; secondarily, evaluate the impact of Chronic obstructive pulmonary disease coexistence on HF in these variables. Methods: This is a multicenter study, in which the patients already gathered in the sampling process in the thematic project will be analyzed and shared. Being this BEPE scholarship approved, a database will be gathered with the patients already gathered in the sampling process from Brazil and Italy, and also the patients to be evaluated during the stay in Italy.HF patients with an ejection fraction of <49% were and will be considered. All patients will perform CPET on an electronically braked cycle ergometer and respiratory gas analysis will be measured breath-by-breath. During CPET, the following parameters were and will be measured: VO2 (ml/kg/min), Ventilation (VE), VCO2 (ml/min), VE/VCO2 slope, WR (watts), Heart rate peak (bpm), SBP and DBP. New risk and prognosis indexes in the population that will be further analyzed: VEint, VO2/WR, CP and VP. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOULART, CASSIA DA LUZ; CARUSO, FLAVIA ROSSI; DE ARAUJO, ADRIANA SANCHES GARCIA; MOURA, SILVIA CRISTINA GARCIA DE; CATAI, APARECIDA MARIA; AGOSTONI, PIERGIUSEPPE; MENDES, RENATA GONCALVES; ARENA, ROSS; BORGHI-SILVA, AUDREY. an Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 8, . (20/13465-5, 18/03233-0)
C.F. FAGUNDES; L. DI THOMMAZO-LUPORINI; C.L. GOULART; D. BRAATZ; A. DITOMASO; A. BORGHI-SILVA. Reference equations of oxygen uptake for the step test in the obese population. Brazilian Journal of Medical and Biological Research, v. 55, . (20/13465-5, 18/03233-0, 15/26501-1)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.