Advanced search
Start date

Investigation of a crosstalk pathway between skeletal muscle and sensory neurons: effects of physical exercise-induced PGC-1a1 in skeletal muscle on dorsal roots ganglion activation and metabolism

Grant number: 20/10585-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): February 01, 2021
Effective date (End): January 31, 2022
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Maria Cláudia Gonçalves de Oliveira
Grantee:Graciana de Azambuja
Supervisor: Jorge Manuel Lira Gonçalves Ruas
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Research place: Karolinska Institutet, Sweden  
Associated to the scholarship:18/13599-1 - Inflammatory mechanisms underlying muscle pain chronification and its prevention by physical exercise: study of macrophages, PPAR gamma and P2X4 receptors involvment, BP.DR


Skeletal muscle has been presented as a highly plastic tissue in response to physical exercise metabolic demands and these effects are relevant for the prevention of several diseases. Little is known about how much physical exercise metabolic adaptations in the skeletal muscle tissue may be related to the resolution of inflammatory pain in the nociceptive primary neurons and prevention of chronic muscle pain. Also, it is not known whether exercise-induced PGC-1± in skeletal muscle is related with this process. There is a crosstalk process where skeletal muscle modifications may modulate other tissues and organs, and PGC-1± is a key factor in many of these pathways. With this, we hypothesize that physical exercise-induced PGC-1± in skeletal muscle will induce modification on DRG neurons in inflammatory pain and that these may be related with an aerobic metabolism in the DRG neurons and skeletal muscle. In order to investigate this, in vivo and in vitro experiments focusing on the tissues' crosstalk will be conducted in this project. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: