Evaluation of antibacterial and biological activity of B-TCP/S53P4 scaffolds obtained by robocasting and coated by tea tree oil

Abstract

Bone defects and treat infections are a big challenge for medicine. In this context tissue engineering has been growing with the advances in scaffolds development. The use of 3D printing to scaffolds production it's an interesting way to obtain a biomaterial with architecture controlled and custom as the patient necessity. Scaffolds based on bioceramics as B-TCP and S53P4 have great biological activities. B-TCP has a high resorption speed and S53P4 bioglass has high biocompatibility and antibacterial activity. To improve those the bactericidal properties, it could be impregnated tea tree oil on the scaffolds. This type of essential oil has antibacterial action that could treat bone infections. Thereby, this project aims to evaluate the biological response and antibacterial activity of B-TCP/S53P4 scaffolds as a synthetic bone graft candidate to application on tissue engineering. In addition, it will be studied the scaffolds' coating with tea tree oil to improve the scaffold antimicrobial activity, expanding its application also for bone infections treatment. (AU)