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Evaluation of antibacterial and biological activity of B-TCP/S53P4 scaffolds obtained by robocasting and coated by tea tree oil

Grant number: 20/12944-7
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): November 14, 2020
Effective date (End): March 25, 2021
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Eliandra de Sousa Trichês
Grantee:Ana Paula Nogueira Alves
Supervisor: Aldo R. Boccaccini
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Research place: Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany  
Associated to the scholarship:19/08141-9 - B-TCP/BG S53P4 ceramic pastes rheological parameters optimization to scaffolds production by robocasting method, BP.MS


Bone defects and treat infections are a big challenge for medicine. In this context tissue engineering has been growing with the advances in scaffolds development. The use of 3D printing to scaffolds production it's an interesting way to obtain a biomaterial with architecture controlled and custom as the patient necessity. Scaffolds based on bioceramics as B-TCP and S53P4 have great biological activities. B-TCP has a high resorption speed and S53P4 bioglass has high biocompatibility and antibacterial activity. To improve those the bactericidal properties, it could be impregnated tea tree oil on the scaffolds. This type of essential oil has antibacterial action that could treat bone infections. Thereby, this project aims to evaluate the biological response and antibacterial activity of B-TCP/S53P4 scaffolds as a synthetic bone graft candidate to application on tissue engineering. In addition, it will be studied the scaffolds' coating with tea tree oil to improve the scaffold antimicrobial activity, expanding its application also for bone infections treatment. (AU)

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