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Late effects of bisphenol A exposure in the mammary gland of female gerbils during pregnancy and lactation

Grant number: 20/01240-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2020
Effective date (End): February 28, 2022
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Sebastião Roberto Taboga
Grantee:Thalles Fernando Rocha Ruiz
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil


The mammary gland composes an associated organ of the female reproductive system affected by steroid hormones. Females in the senile phase present a tendency in neoplasms development and tumors in mammary tissue. Therefore, some endocrine disruptors, like bisphenol A (BPA), have been studied due its potential to promote tumor inflammations and cancer in associated organs of the reproductive system. BPA exposure during lactation can alter estrogen receptors and develop persistent neoplasms. Thus, the present study aims to evaluate the disruptor potential of BPA in the mammary gland of aged female gerbils (Meriones unguiculatus), an experimental model that present spontaneous neoplasms development. Five nulliparous females and fifteen lactating females will be used, divided into 4 experimental groups: group 1 - nulliparous; group 2 - oil control; group 3 - low-dose BPA (50 µg/kg); and group 4 - high-dose BPA (5000 µg/kg). The histopathological aspects of the gland will be analyzed: parameters of the epithelium, myoepithelial cells, and stroma fibers. By immunohistochemistry will be analyzed the expression of inflammatory marks TNFa, F4/80 macrophage protein, and metalloproteinases, as well as estrogen (ERa and ERß) and progesterone receptors. It is expected to observe the deleterious effects of BPA in the context of morphological changes and changes in the expression pattern of inflammatory markers in the analyzed tissue. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RUIZ, THALLES F. R.; COLLETA, SIMONE J.; DOS SANTOS, DIEGO D.; CASTRO, NAYARA F. C.; CABRAL, AGATA S.; CALMON, MARILIA F.; RAHAL, PAULA; GIL, CRISTIANE D.; GIROL, ANA PAULA; VILAMAIOR, PATRICIA S. L.; et al. Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response. Cell Biology International, v. 47, n. 6, p. 11-pg., . (20/00160-1, 18/23383-6, 20/01240-9)
RUIZ, THALLES F. R.; GRIGIO, VITOR; FERRATO, LUARA J.; DE SOUZA, LORENA G.; COLLETA, SIMONE J.; AMARO, GUSTAVO M.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; LEONEL, ELLEN C. R.; TABOGA, SEBASTIA O. R.. Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females. Molecular and Cellular Endocrinology, v. 566, p. 11-pg., . (21/14140-5, 22/00521-0, 18/23383-6, 20/00160-1, 20/01240-9)
ROCHA RUIZ, THALLES FERNANDO; RIVAS LEONEL, ELLEN CRISTINA; COLLETA, SIMONE JACOVACI; BEDOLO, CAROLINA MARQUES; PEGORIN DE CAMPOS, SILVANA GISELE; TABOGA, SEBASTIAO ROBERTO. Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v. 89, p. 13-pg., . (20/01240-9, 18/23383-6)
RUIZ, THALLES FERNANDO ROCHA; TABOGA, SEBASTIAO ROBERTO; LEONEL, ELLEN CRISTINA RIVAS. Molecular mechanisms of mammary gland remodeling: A review of the homeostatic versus bisphenol a disrupted microenvironment. REPRODUCTIVE TOXICOLOGY, v. 105, p. 1-16, . (20/01240-9, 18/23383-6)
ROCHA RUIZ, THALLES FERNANDO; COLLETA, SIMONE J.; LEONEL, ELLEN C. R.; TABOGA, SEBASTIAO ROBERTO. ammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactatio. Endocrine-Related Cancer, v. 28, n. 11, p. 715-730, . (20/01240-9, 18/23383-6, 20/00160-1)
RIVAS LEONEL, ELLEN CRISTINA; ROCHA RUIZ, THALLES FERNANDO; BEDOLO, CAROLINA MARQUES; PEGORIN CAMPOS, SILVANA GISELE; TABOGA, SEBASTIAO ROBERTO. Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-beta estradiol. Cell Biology International, v. 45, n. 11, . (18/23383-6, 20/01240-9)
ROCHA RUIZ, THALLES FERNANDO; COLLETA, SIMONE JACOVACI; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA; LEITE VILAMAIOR, PATRICIA SIMONE; RIVAS LEONEL, ELLEN CRISTINA; TABOGA, SEBASTIAO ROBERTO. Hormone receptor expression in aging mammary tissue and carcinoma from a rodent model after xenoestrogen disruption. Life Sciences, v. 285, . (18/23383-6, 20/01240-9, 20/00160-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RUIZ, Thalles Fernando Rocha. Late effects of bisphenol A exposure in the mammary gland of female gerbils during pregnancy and lactation. 2022. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.

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