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Development of a biophysical model for chromosome aberrations induced by ionizing radiations

Grant number: 20/05666-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2020
Effective date (End): March 31, 2021
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal researcher:Mario Antonio Bernal Rodriguez
Grantee:Farhad Moradi
Home Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:18/15316-7 - Study of the interaction of heavy charged particles with DNA using computational methods, AP.JP2

Abstract

Radiation-DNA interaction can induce biological damages, including Câncer. Paradoxically, this disease can be treated with these radiations, which is known as Radiation Therapy. Along the last decade, the use of proton beams in Radiation Therapy (protontherapy) has increased very fast. However, the mechanisms involved in the DNA damage induced by these particles are not well known yet. This project aims at the development of a biophysical model for estimating the Relative Biological Effectiveness (RBE) from the capacity of ionizing radiations for inducing chromosome aberrations. Recently, our group introduced the indirect damage on the DNA, induced by chemical species coming from the water radiolysis. We are also working on the development of very realistic chromosome geometrical models. Thus, we are ready for going a step further from current models, in order to determine DSB cluster yields and chromosome aberrations. This way, we expect to estimate the RBE for diverse radiation qualities, such as photons, electrons, ions and neutrons. (AU)

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