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Meta-analysis: the association between parent's age in pregnancy and risk for diagnosis of bipolar affective disorder in children

Grant number: 20/05087-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2021
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Beny Lafer
Grantee:Natália Polga
Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Bipolar disorder (BD) is associated with significant burden to individuals and to society, leading to a higher rate of disability adjusted life years (DALYs) than rheumatic fever, Parkinson's disease and multiple sclerosis combined in Brazil. Despite its importance as a public health problem, BD usually presents a significant delay until diagnosis, averaging between 5 to 10years after the onset of symptoms. In this context, it is of utmost importance to identify risk factors that increase the clinician's suspicion for the presence of BD. The age of parents in pregnancy has emerged as a significant risk factor for various mental disorders, but no study has yet been conducted meta-analyzing the individual reports in the literature. Objective: To conduct a systematic review and meta-analysis of epidemiological studies reporting data on parental age at pregnancy and diagnosis of BD in the offspring.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROTENBERG, LUISA DE SIQUEIRA; BORGES-JUNIOR, RENATO GOMES; LAFER, BENY; SALVINI, ROGERIO; DIAS, RODRIGO DA SILVA. Exploring machine learning to predict depressive relapses of bipolar disorder patients. Journal of Affective Disorders, v. 295, p. 681-687, . (20/05087-0, 18/11963-8, 17/07089-8)
TATIANA COHAB KHAFIF; ANA KLEINMAN; LUISA DE SIQUEIRA ROTENBERG; BENY LAFER. Emotion regulation and the COVID-19 pandemic: a practical guide to rehabilitating children and adolescents. Revista Brasileira de Psiquiatria, v. 44, n. 3, p. 235-236, . (17/07089-8, 20/05087-0, 18/11963-8)

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