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B-alanine supplementation associated with high-intensity interval training on modulations of the immune-endocrine response in healthy adults

Grant number: 19/25282-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2020
Effective date (End): December 31, 2021
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Alessandro Moura Zagatto
Grantee:Barbara de Moura Mello Antunes
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Chronic use of ergogenic resources, such as b-alanine, is widely investigated given its positive effects on performance and physical training quality. However, is unclear the knowledge about the effects of the quality of physical training, enhanced by b-alanine, on the anti-inflammatory responses, typically associated with exercise training, on systemic and tissue levels. Thus, the purpose of the present project will be to investigate the effects of 12 weeks of b-alanine supplementation associated with high-intensity interval training on intramuscular and systemic inflammatory modulations. In this perspective, 20 healthy volunteers will be recruited and divided randomly into b-alanine (6.4 or placebo (dextrose) groups that, after 6 weeks of supplementation, will performed 6 weeks of high-intensity interval training, associated with supplementation, in a sprint protocol (10 sprints with 1min effort: 1 min pause) with frequency of three sessions/weekly. Pre and post-intervention, body composition, nutritional habits, cardiorespiratory fitness, blood collection and muscle biopsy will be collected. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONETTI DE POLI, RODRIGO ARAUJO; FIALHO LOPES, VITHOR HUGO; LIRA, FABIO SANTOS; ZAGATTO, ALESSANDRO MOURA; JIMENEZ-MALDONADO, ALBERTO; ANTUNES, BARBARA MOURA. Peripheral BDNF and psycho-behavioral aspects are positively modulated by high-intensity intermittent exercise and fitness in healthy women. SCIENTIFIC REPORTS, v. 11, n. 1, . (19/22726-0, 19/17445-1, 19/25282-5, 18/21126-6)
OLEAN-OLIVEIRA, TIAGO; FIGUEIREDO, CAIQUE; DE POLI, RODRIGO ARAUJO BONETTI; LOPES, VITHOR HUGO FIALHO; JIMENEZ-MALDONADO, ALBERTO; LIRA, FABIO SANTOS; ANTUNES, BARBARA MOURA. Menstrual cycle impacts adipokine and lipoprotein responses to acute high-intensity intermittent exercise bout. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 122, n. 1, . (19/26378-6, 19/22726-0, 19/17445-1, 19/11340-3, 19/25282-5)
ZAGATTO, ALESSANDRO M.; BISHOP, DAVID J.; ANTUNES, BARBARA MOURA; BECK, WLADIMIR R.; MALTA, ELVIS S.; DE POLI, RODRIGO A. B.; CAVAGLIERI, CLAUDIA R.; CHACON-MIKAHIL, MARA PATRICIA T.; CASTRO, ALEX. Impacts of high-intensity exercise on the metabolomics profile of human skeletal muscle tissue. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 32, n. 2, . (20/13939-7, 17/21724-8, 19/25282-5, 18/21126-6)

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