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Study of antitumor activity of biogenic silver nanoparticles

Grant number: 20/04799-7
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2024
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Ana Olívia de Souza
Grantee:Gabriella Sales Calaço Roque
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Data from the United States National Cancer Institute show that death rates from cancer have increased over the years, and the available therapy indicates adverse effects on patients, requiring new alternatives. Biological silver nanoparticles (AgNPs) can be a viable possibility as antitumor treatment, since the protective coating favors its affinity for tumor cells and, consequently, can contribute to the adverse effects reduction. Due to the antitumor agents demand and the potential for applying AgNPs, the aims of this proposal is to study the in vitro and in vivo antitumor action of biogenic AgNPs, based on the cultivation of extremophile fungi from Brazilian biodiversity, such mainly from mangrove and biome Caatinga. It is intended that the study will contribute to providing subsidies and data for a new alternative to current antitumor treatments, with a reduction or absence of adverse effects. (AU)

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