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Comparative evaluation between Endobon® associated with i-PRF and autogenous bone graft in the human maxillary sinus: histomorphometric analysis

Grant number: 20/08694-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2021
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Eduardo Hochuli Vieira
Grantee:Nádia Meneghel Fusato
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Early tooth loss directly affects the quality of life of patients due to changes in the stomatognathic system, in addition to causing losses in social acceptance resulting mainly from aesthetic issues. Thus, oral rehabilitation is convenient through the installation of osseointegrated implants and dental prostheses. However, the progressive resorption of the residual alveolar ridge and pneumatization of the maxillary sinus may prevent the installation of these osseointegrated implants in the posterior region of the maxilla due to inadequate bone quantity and quality. Therefore, surgical intervention is necessary through the elevation of the sinus membrane and the use of bone grafts in an attempt to reconstruct this lost area. The autogenous bone graft remains the gold standard for reconstruction of areas that present bone defects, due to their osteoconductive, osteoinductive and osteogenic capacity. However, due to the need for another surgical site and limited quantity, biomaterials were developed in an attempt to replace the use of autogenous bone. The aim of this study is to evaluate, through histomorphometric analysis, the behavior of the biomaterial Endobon®, which has characteristics similar to the human medullary bone, associated with i-PRF, an autologous growth factor, and to compare it to the graft performed with autogenous bone, in addition to describing its characteristics and classifying the quality of this biomaterial for bone grafting in human maxillary sinuses.

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