Advanced search
Start date

The use of L-carnitine compared tò placebo ín mortality of sepsis patients: systematic review and meta-analysis

Grant number: 20/02135-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Suzana Erico Tanni Minamoto
Grantee:Gabriel Voltani Guedes
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Sepsis and septic shock are severe diseases, with high lethality rates and of complex hospitalar management. These diseases derive from the dysregulation of the patient's immunologic response to a given infection. Currently, sepsis therapy is limited to hemodynamic and ventilatory support (through the use of mechanical ventilation, vasopressors and cardiotropic drugs), parallel to the treatment of the underlying infection. Thus, in the search for new adjuvant therapies, the administration of L-carnitine has emerged, with its activity upon mitochondrial energy metabolism. Considered low-risk, it has been gaining attention despite lacking evidence. Therefore, in this study a systematic review and meta-analysis will be performed regarding the safety and efficacy of the use of L-carnitine, administered independently, in comparison to placebo, in the mortality rates of hospitalized septic patients.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: