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Clinical outcomes of pain and repair after photobiomodulation and antimicrobial photodynamic therapy by red laser (660nm) in weekly sessions: randomized crossover clinical trial

Grant number: 20/05149-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2020
Effective date (End): December 31, 2021
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Maria Cristina Zindel Deboni
Grantee:Beatriz Campos Pereira
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The effectiveness of the anti-inflammatory, analgesic and photobiomodulatory effects of the laser is known, as well as its antimicrobial effect when the associated antimicrobial photodynamic therapy (aPDT) is applied, in patients with lesions or at increased risk, such as osteonecrosis jaws by medication. However, the role of aPDT as an adjuvant therapy for the best postoperative repair of dental surgeries in healthy patients is still poorly studied. The clinical relevance of our proposal lies precisely in the growing need that currently exists to find therapies that assist the postoperative period of dental surgeries, and that are not related to undesirable or adverse health effects, as is the case with analgesics and anti-inflammatory drugs. inflammatory effects for long-term use. Twenty patients from the Dental Surgery Clinic of FOUSP will be selected after a clinical and radiographic examination and a random clinical trial will be carried out, such as "split-mouth". Voluntary participants between 18 and 35 years old with the need for extraction of semi-included or included bilateral third molars with similar degree of surgical difficulty will be included. Third molar extraction is ideal for such a study, since it allows us to analyze the effects of photodynamic therapy on the same individual comparatively, eliminating variations of individual character. In addition, as it is an often complex procedure, and relatively traumatic to the tissues and, therefore, involves a postoperative period that frequently presents reports of pain, edema and inflammation, it allows us to assess these variables more easily. The sample will be randomly distributed in aPDT or Sham Group. The analysis of clinical outcomes will be evaluated comparatively between the groups in the same patient considering the levels of postoperative pain in different periods using the Visual Analogue Scale (VAS), the amount of analgesic consumed, and the clinical characteristics of the repair in 24h, 7 and 14 days after surgery.

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