Influence of integrative and conjugative elements (ices) from the SXT/R391 family on physiological and pathogenic aspects of Proteus mirabilis

Abstract

Conjugative and integrative elements (ICEs) from the SXT/R391 family are frequently found in bacteria of the genera Vibrio, Proteus and Morganella, among others. These elements often carry antimicrobial resistance genes, considered important agents in the spread of resistance. However, many elements present in Proteus mirabilis lack these genes, but harbor several of unknown function, unrelated to the basic functions of excision, conjugation and integration. This observation has led to the speculation about which adaptive advantages, in addition to resistance to antimicrobials, these elements may provide for host cells. In this project, we will investigate the role of these elements in the physiology of the pathogen Proteus mirabilis. Isogenic strains containing or not this element will be evaluated for pathogenicity, biofilm formation, motility, development of persistent cells and fitness. (AU)