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Bioactive metabolites of bacterial flora microorganisms from non-filtering marine animals

Grant number: 20/01229-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Marcelo Rodrigues de Amorim
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):22/15570-6 - Investigating the biosynthesis of cytochalasans from the marine-derived fungus Peroneutypa sp. M16, BE.EP.PD


Very little is known about the microbial diversity of microorganisms associated with non-filtering marine organisms. Thus, it is necessary to investigate the microbiota of different non-filtering marine organisms, and the secondary metabolism of these strains, in order to verify if the secondary metabolism expressed by these strains is significantly different from cosmopolitan microbial strains. The present project aims to respond, albeit partially, to the following questions: a) Bacterial strains isolated from the viscera of non-filtering marine animals are, for the most part, not yet described from a taxonomic point of view?; b) Secondary metabolism of bacterial strains isolated from non-filtering marine animals is significantly distinct from that observed for microorganisms of wide occurrence in nature? Thus, in this project, the aims are: a) to identify strains of bacteria isolated from non-filtering marine organisms; b) to perform dereplication of these species of bacteria, using HPLC-UV-MS and UPLC-qTOF-MS, statistical and chemometric analyses in conjunction with different databases (GNPS-Molecular Networking, Dictionary of Natural Products and SciFinder); c) carry out the chemical and biological investigation of at least two strains of the bacteria identified and analyzed in their metabolome. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE AMORIM, MARCELO R.; BARBOSA, CAMILA DE S.; PAZ, TIAGO A.; IOCA, LAURA P.; NICACIO, KAREN J.; DE OLIVEIRA, LUCIANNE F. P.; GOULART, MIRIAN O.; PAULINO, JULIA M.; DA CRUZ, MATEUS O.; FERREIRA, ANTONIO G.; et al. Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.. Journal of Natural Products, v. 86, n. 6, p. 11-pg., . (19/17721-9, 16/05133-7, 15/01017-0, 20/12904-5, 20/01229-5)
TAKAKI, MIRELLE; WILLIAMS, DAVID E.; FREIRE, VITOR F.; SARTORI, SERGIO B.; LIRA, SIMONE P.; BIZARRIA JR, RODOLFO; RODRIGUES, ANDRE; DA COSTA, DANIELLE R. GONCALVES; AMORIM, MARCELO R. .; FERREIRA, ANTONIO G.; et al. Metabolomics Reveals a 26-Membered Macrolactone Produced by Endophytic Colletotrichum spp. from Alcatrazes Island, Brazil. ORGANIC LETTERS, v. N/A, p. 5-pg., . (20/01229-5, 13/50228-8, 18/03679-8, 15/14114-3, 19/17721-9)
OLIVEIRA, LEANDRO DA SILVA; CRNKOVIC, CAMILA M. M.; DE AMORIM, MARCELO R. R.; NAVARRO-VAZQUEZ, ARMANDO; PAZ, TIAGO A. A.; FREIRE, VITOR F. F.; TAKAKI, MIRELLE; VENANCIO, TIAGO; FERREIRA, ANTONIO G. G.; SAITO, RENATA DE FREITAS; et al. Phomactinine, the First Nitrogen-Bearing Phomactin, Produced by Biatriospora sp. CBMAI 1333. Journal of Natural Products, v. N/A, p. 8-pg., . (13/50228-8, 19/00447-1, 20/01229-5, 19/17721-9)
BARROS, ELCIO DANIEL SOUSA; MONCAO FILHO, EVALDO DOS SANTOS; PIO, YARA POLIANNA FONSECA; DE AMORIM, MARCELO RODRIGUES; BERLINCK, ROBERTO G. S.; MOURA, RITA DE CASSIA; FONSECA, MARILUCE GONCALVES; DANTAS, CLECIO; COELHO, RONALDO CUNHA; DA SILVA, GUILHERME RAMOS; et al. Comparative study of composition of methanolic extracts of the paratoid gland secretions (PGS) of Rhinella jimi (cururu toad) from northeastern Brazil: Gender, seasonality and geographic occurrence. Toxicon, v. 214, p. 10-pg., . (19/17721-9, 20/01229-5, 13/50228-8, 15/01017-0)

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