The role of renin-angiotensin system on bone metabolism of the mandible of diabetic mice with induced-periodontal disease

Abstract

Periodontal disease (PD) is considered an inflammation that destroys the tissue supporting the teeth - alveolar bone, periodontal ligament, cementum and gums. There are several studies that link periodontitis to diabetes mellitus, since diabetes mellitus increases the severity of PD. One of the mediators involved in the inflammatory process of PD is angiotensin. The renin-angiotensin system (RAS), in addition to inflammation, is also associated with bone turnover by the action of angiotensin that acts indirectly on bone cells through the vascular flow of the bone marrow or by the release of inflammation mediators that increase vascularization endothelial that stimulates osteoclastogenesis. Thus, the present study proposes to evaluate the role of the RAS on the bone metabolism of the mandible of diabetic mice submitted to induced-periodontitis. For this purpose, male Balb / c mice, diabetic or not, submitted to PD and treated or not with aliskiren, a renin inhibitor, will be used. In this study, bone markers of osteoclastic activity in the mandible and their relationship with renin will be evaluated, as well as cytokines and chemokines that may be involved in the process. The results of comparative analysis of histomorphometric, immunological and molecular data will certainly contribute to the improvement of the knowledge involved in the molecular and cellular mechanisms of bone metabolism necessary for the repair of bone tissue, thus being able to collaborate for the development of new therapies for the control of periodontitis in the presence of diabetes. (AU)