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Influence of zigosity and fetal parameters on dental caries, on the behavior during detal tratament and on quality of life of children: a cohort study in twins

Grant number: 19/27560-2
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): July 01, 2020
Effective date (End): December 31, 2024
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Fausto Medeiros Mendes
Grantee:Julia Gomes Freitas
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Twin studies are an excellent experimental model to investigate to oral health factors that could be related to genetics, pre-and perinatal factors and to the environment. Therefore, the aim of the present study will be to evaluate in a cohort of twins, the influence of zigosity and other variables on the behavior during the dental treatment, dental caries, quality of life, improvement of quality of life and success of the dental treatment after 2 years. Thus, a historical cohort study with twins born at the Hospital das Clínicas da Faculdade de Medicina (FM) da Universidade de São Paulo (USP) from 2007 to 2014 will be conducted. For this, a collaboration with researchers from FMUSP and from the Instituto de Psicologia (IP) da USP will be created. These children, currently aged from5 to 12 years old, will be invited to attend initially at the IP, and after, to the Faculdade de Odontologia da USP. Data related to the prenatal, perinatal and zigosity will be gathered from the medical records from the FM. Other demographic, socioeconomic data, as well as data from the childhood will be collected though structured questionnaires applied to the mothers. The pairs of twins initially will have their teeth examined by clinical inspection to evaluate the oral health conditions, and a treatment plan will be elaborated. In the subsequent appointments, dental treatment will be conducted and the children's behavior during the treatment will be assessed. A questionnaire to evaluate the impact of oral health on children's quality of life will be applied at the beginning of the study and one week after the end of the dental treatment. After that, children will be followed-up for two years, and the success of the dental treatment will be evaluated through number of new operative interventions during the follow-up. Multilevel regression analyses (first level related to the subject and the second level related to the pairs of twins) will be performed to investigate the association of all outcome variables with zigosity, data related to the pre- and perinatal, and other variables collected. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FREITAS, JULIA GOMES; ANTUNES PONTES, LAURA REGINA; ACOSTA, CAROLINA DE PICOLI; NOVAES, TATIANE FERNANDES; LARA, JUAN SEBASTIAN; GIMENEZ, THAIS; ARDENGHI, THIAGO MACHADO; BRAGA, MARIANA MINATEL; RAGGIO, DANIELA PROCIDA; MENDES, FAUSTO MEDEIROS; et al. Influence of two caries detection strategies on the quality of life of preschool children: An analysis of secondary outcomes of a 2-Year randomized clinical trial. COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY, v. N/A, p. 9-pg., . (17/16665-2, 19/27560-2)

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