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Development and application of multifunctional nanocarriers for intraductal delivery of chemotherapy aiming at Breast Cancer treatment

Grant number: 19/26048-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2020
Effective date (End): May 31, 2025
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Luciana Biagini Lopes
Grantee:Giovanna Cassone Salata
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors, AP.JP2
Associated scholarship(s):22/07303-8 - Development and efficacy of a lipid nanocarrier loaded with mRNA intended for transient CAR-T response in acute lymphoblastic leukemia treatment, BE.EP.DR

Abstract

In this project, we propose the development and evaluation of nanoemulsions functionalized with hyaluronic acid for localized intraductal treatment of Ductal Carcinoma In Situ and other breast lesions (which increase the risk for development of invasive forms of Breast Cancer) combining efficacy, selectivity and reduction of systemic adverse effects of chemotherapy. In order to potentialize the cytotoxic effects and reduce resistance, we propose the co-incorporation of 3 active compounds: (i) paclitaxel, a cytotoxic agent, effective in various types of tumors, (ii) elacridar, a potent inhibitor of efflux transporter P-gp, associated with the development of resistance to chemotherapy (including paclitaxel) and (iii) perillyl alcohol, a monoterpene capable of potentializing the cytotoxic effect of other compounds. After nanoemulsion obtainment and characterization, we will assess the cellular effects and application of the nanocarriers in 2D and 3D models, cell uptake, mammary retention and efficacy in an animal model of chemically induced carcinogenesis. With this project, we aim to contribute to the development of a localized, more effective and safer platform for Breast Cancer treatment. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA-FERNANDEZ, SANDRA; MATOS, JENYFFER K. R.; SCHEUNEMANN, GABY S.; SALATA, GIOVANNA C.; CHORILLI, MARLUS; WATANABE, IL-SEI; DE ARAUJO, GABRIEL L. B.; SANTOS, MARINILCE F.; ISHIDA, KELLY; LOPES, LUCIANA B.. Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing. International Journal of Biological Macromolecules, v. 183, p. 668-680, . (14/50928-2, 19/26048-6, 13/16617-7, 15/07993-0, 17/19374-9, 18/13877-1)
DONADON, LARISSA GABRIELLA FUSCO; SALATA, GIOVANNA CASSONE; GONCALVES, THALITA PEDRALINO; MATOS, LISA DE CARVALHO; EVANGELISTA, MARIA CLARA PAIVA; DA SILVA, NICOLE SAMPAIO; MARTINS, TEREZA SILVA; MACHADO-NETO, JOAO AGOSTINHO; LOPES, LUCIANA BIAGINI; GARCIA, MARIA TERESA JUNQUEIRA. Monoolein-based nanodispersions for cutaneous co-delivery of methylene blue and metformin: Thermal and structural characterization and effects on the cutaneous barrier, skin penetration and cytotoxicity. International Journal of Pharmaceutics, v. 633, p. 18-pg., . (17/18239-0, 18/13877-1, 17/17844-8, 19/08582-5, 19/26048-6)
MOJEIKO, GABRIELA; APOLINARIO, ALEXSANDRA CONCEICA; SALATA, GIOVANNA CASSONE; CHORILLI, MARLUS; LOPES, LUCIANA B.. Optimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 646, p. 14-pg., . (19/26048-6, 18/14375-0, 19/00196-9, 18/13877-1, 14/50928-2)
PASSOS, JULIA SAPIENZA; DARTORA, VANESSA F. M. C.; SALATA, GIOVANNA CASSONE; MALAGO, ISABELLA DRASZESSKI; LOPES, LUCIANA B.. Contributions of nanotechnology to the intraductal drug delivery for local treatment and prevention of breast cancer. International Journal of Pharmaceutics, v. 635, p. 15-pg., . (18/13877-1, 17/04174-4, 20/01208-8, 14/50928-2, 19/26048-6)

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Filed patent(s) as a result of this research project

NANOFORMULAÇÃO EM GEL POLIMÉRICO ETOSSOMAL E SEU USO NA PREPARAÇÃO DE UM MEDICAMENTO PARA A QUIMIOPREVENÇÃO DO CÂNCER DE MAMA E NA PREVENÇÃO E/OU TRATAMENTO DO CÂNCER DE PELE E CERVICAL BR1020210221771 - Universidade de São Paulo (USP) . LUCIANA BIAGINI LOPES, GIOVANNA CASSONE SALATA, ALEXSANDRA CONCEIÇÃO APOLINÁRIO, GABRIELA MOJEIKO - November 2021, 04