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Thyroid hormones and the relation to the reproductive-somatotropic axis and their possible role in embryonic development in response to maternal stress in Zebrafish (Danio rerio)

Grant number: 19/22997-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2020
Effective date (End): January 31, 2024
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Inland Water Fishery Resources
Principal researcher:Rafael Henrique Nóbrega
Grantee:Maira da Silva Rodrigues
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

In vertebrates thyroid hormones are involved in the regulation of various physiological processes such as growth, metabolism, behavior, stress and reproductive system. In reproduction, our previous results (FAPESP 2017/15793-7; FAPESP BEPE 2018/15319-6) showed strong evidence between thyroid hormones and the hypothalamic-pituitary-gonadal axis in Zebrafish. In addition, thyroid hormones are also important for embryonic development, although high doses of these can be impared to growth and cause mortality. Based on this, the present project will have as objectives: 1) evaluate the molecular mechanisms involved in the interaction of thyroid hormones with Fsh; 2) investigate if a maternal stress increases plasma and ovarian levels of thyroid hormones; and 3) the possible increase in these hormones affects the development of the offspring. To response these objectives, testicular culture, RNAseq, GapmeR technology, histomorphometry, ELISA and gene expression techniques will be employed. Thus, it is expected that the results obtained in this project may generate knowledge about the regulation of thyroid hormones in fish testicular function. Finally, to evaluate the possible involvement of thyroid hormones in maternal stress and their impacts on embryonic development. Overall, this project will contribute to the reproductive physiology of teleost fish, including species of zootechnical interest. (AU)

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