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Use of anaphase promoter complex genes to increase biomass

Grant number: 20/02353-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2020
Effective date (End): March 31, 2022
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Acordo de Cooperação: Max Planck Society for the Advancement of Science
Principal Investigator:Nubia Barbosa Eloy
Grantee:Ingrid Andrade Rocha
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP


The anaphase promoter complex (APC) is a multiprotein complex - an ubiquitin E3 ubiquitin ligase - involved in ubiquitin-dependent proteolysis of cell cycle regulatory proteins, and in which we include the destruction of mitotic cyclins during the metaphase-anaphase transition. The identification of the complete set of genes encoding the APC subunits in Arabidopsis, suggests that the basic processes controlled by ubiquitin-mediated proteolysis in plants are similar to those of other organisms. However, results from several groups indicate that the APC has other specific functions in regulating plant development. In this project, our aim is to use the TAP (Tandem Affinity Purification) and two hybrid technique to identify new genes in the Arabidopsis model plant, with biotechnological potential for increasing biomass, once its potential is confirmed, we will transfer the knowledge obtained in our study with Arabidopsis to a crop of economic interest in Brazil, tomato, in order to produce plants with greater biomass production. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALEME, MARINA DE LYRA SORIANO; ANDRADE, INGRID ROCHA; ELOY, NUBIA BARBOSA. The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction. FRONTIERS IN PLANT SCIENCE, v. 12, . (20/00888-5, 20/02353-1, 17/10333-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ROCHA, Ingrid Andrade. Characterization of the Anaphase Promoting Complex Subunit 4 (APC4) in Arabidopsis thaliana. 2023. Master's Dissertation - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALA/BC) Piracicaba.

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