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Study of the influence of nanocarriers and drug combinations on cell viability and migration

Grant number: 20/04633-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2020
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Luciana Biagini Lopes
Grantee:Isabella Draszesski Malagó
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors, AP.JP2

Abstract

Chemoprevention is an important strategy for reduction of breast cancer incidence. However, women's adherence to the currently available strategies is very low mostly because of the severe adverse effects. Our group has been focusing on the development and evaluation of nanocarriers containing drug combinations as potential new strategies for pharmacological prevention of breast cancer. In this project, we will assess whether and how (i) nanoencapsulation and (ii) combination of drugs influence the viability and migration of breast cancer (MCF7 and T47D) cells. Additionally, effects on non-tumoral (MCF10) cells will be assessed to verify safety and selectivity. We will focus on combinations of piplartine, fenretinide, 5-fluorouracyl and perillyl alcohol to determine additive and synergistic effects, and these drugs will be incorporated at selected combinations in lipid nanocarriers.

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