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APC as an entry point to study small molecule regulation of the cell cycle

Grant number: 20/00888-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2020
Effective date (End): May 31, 2021
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Cooperation agreement: Max Planck Society for the Advancement of Science
Principal researcher:Nubia Barbosa Eloy
Grantee:Marina de Lyra Soriano Saleme
Home Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated research grant:17/10333-8 - APC as an entry point to study small molecule regulation of the cell cycle, AP.JP

Abstract

The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that plays a major role in the progression of the eukaryotic cell cycle. This unusual protein complex targets key cell-cycle regulators, such as mitotic cyclins and securins, for degradation via the 26S proteasome by ubiquitination, triggering the metaphase-to-anaphase transition and exit from mitosis. The identification of the complete set of genes encoding subunits of the APC in Arabidopsis suggests that the basic processes controlled by proteolysis mediated by ubiquitin in plants are similar to those of other organisms. However, results from several groups indicate that the APC has other specific functions in the regulation of plant development. During the last years, several molecular-biology tools have been extensively used in scientific research for identifying new function of proteins and metabolites. Still, the identification of metabolites, specially which control the cell cycle is not trivial and is characterized by piecemeal progress, especially in plants. In this project we aim to use metabolomics to identify and characterize metabolites that bind to the APC in the model plant Arabidopsis, and to potentially define their roles in plant development. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALEME, MARINA DE LYRA SORIANO; ANDRADE, INGRID ROCHA; ELOY, NUBIA BARBOSA. The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction. FRONTIERS IN PLANT SCIENCE, v. 12, FEB 24 2021. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.