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Functional characterization of the calcium-dependent signaling pathway in the regulation of cellulases expression by the fungus Trichoderma reesei

Grant number: 19/19569-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2020
Effective date (End): June 30, 2023
Field of knowledge:Biological Sciences - Biochemistry - Biochemistry of Microorganisms
Principal Investigator:Roberto do Nascimento Silva
Grantee:Letícia Harumi Oshiquiri
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The lignocellulosic biomass from plant-derived waste can be converted into second-generation biofuels in a process that requires the deconstruction of this material into smaller and simpler molecules. The fungus Trichoderma reesei produces enzymes, such as cellulases, that are involved in the hydrolysis of the lignocellulosic biomass; however, due to the high costs of production, optimization is still necessary for the viability of the process. This project aims to contribute to the understanding of the calcium-related molecular mechanisms that are involved in the regulation of the expression of T. reesei cellulases trough functional characterization of 5 calcium transporters, involved in the calcium-dependent signaling pathway, which were previously identified by the group during T. reesei cultivation in the presence of cellulose, soforose and sugarcane bagasse. The characterization will be performed by constructing mutant strains for each gene and then determining the effects elicited. The results obtained from this study will allow the elaboration of a model relating the role of the calcium-dependent signaling pathway in the regulation of cellulose expression by T. reesei, enabling the identification of new targets for the optimization of the lignocellulosic biomass degradation process. (AU)

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