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Use of nanostructured carriers to load combined antibiotics

Grant number: 18/03666-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2020
Effective date (End): April 20, 2023
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Laura de Oliveira Nascimento
Grantee:Viviane Lucia Beraldo de Araújo
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Recent researches have shown that, in general, the combined treatment of antibiotics exhibits greater performance than monotherapies. In particular, the treatment of bacterial infections that may cause meningitis - a disease that presented nearly 110 thousands new cases between 2000 and 2010 in Brazil - showed superior results of the combined treatment with ceftriaxone and levofloxacin, when compared to standard treatment. However, levofloxacin, a third generation antibiotic from fluorquinolones class, cause adverse effects, such as nerve and tendon damages. To overcome these, it is useful the application of nanotechnology. In such a context, this research project propose to develop processes and formulations of nanostructured lipid carriers (NLC), the newest generation of lipid nanocarriers, to a combined parenteral administration of levofloxacin and ceftriaxone. The development of process and product will involve design of experiments to study interactions drug-excipient and reach information about their influences on potency/synergy between the drugs; physicochemical analysis; cellular viability and permeability in a mimetic model of a human blood brain barrier. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERALDO-ARAUJO, VIVIANE LUCIA; SIQUEIRA VICENTE, ANA FLAVIA; LIMA, MARCELO VAN VLIET; UMERSKA, ANITA; SOUTO, ELIANA B.; TAJBER, LIDIA; OLIVEIRA-NASCIMENTO, LAURA. Levofloxacin in nanostructured lipid carriers: Preformulation and critical process parameters for a highly incorporated formulation. International Journal of Pharmaceutics, v. 626, p. 13-pg., . (20/08059-8, 19/09719-4, 18/03666-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ARAÚJO, Viviane Lucia Beraldo de. Carreadores nanoestruturados para veiculação de levofloxacino como potencial tratamento de infecções pulmonares. 2023. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas Campinas, SP.

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