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Use of nanostructured carriers to load combined antibiotics

Grant number: 18/03666-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2020
Effective date (End): November 20, 2022
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Laura de Oliveira Nascimento
Grantee:Viviane Lucia Beraldo de Araújo
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Recent researches have shown that, in general, the combined treatment of antibiotics exhibits greater performance than monotherapies. In particular, the treatment of bacterial infections that may cause meningitis - a disease that presented nearly 110 thousands new cases between 2000 and 2010 in Brazil - showed superior results of the combined treatment with ceftriaxone and levofloxacin, when compared to standard treatment. However, levofloxacin, a third generation antibiotic from fluorquinolones class, cause adverse effects, such as nerve and tendon damages. To overcome these, it is useful the application of nanotechnology. In such a context, this research project propose to develop processes and formulations of nanostructured lipid carriers (NLC), the newest generation of lipid nanocarriers, to a combined parenteral administration of levofloxacin and ceftriaxone. The development of process and product will involve design of experiments to study interactions drug-excipient and reach information about their influences on potency/synergy between the drugs; physicochemical analysis; cellular viability and permeability in a mimetic model of a human blood brain barrier. (AU)

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