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Incorporation of silver nanoparticles and drugs into flexible polyamide 12 membranes

Grant number: 19/20214-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Eduardo José Nassar
Grantee:Maria Gabriela Martins de Souza
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

In order to meet the needs of the market and of the community as a whole, nanostructured polymeric materials are constantly being developed for use in the biomedical field. These materials have potential applications in the field of drug delivery devices, which aim at delivering controlled drug dosage to specific regions of the organism, thereby increasing drug efficacy and safety and reducing the possible adverse effects that said the same drug would have if administered by other means. For example, indomethacin, a non-steroidal anti-inflammatory agent with potential action in painful conditions, is detrimental to the gastrointestinal system when it is continuously taken via oral administration. In parallel, the intensified antimicrobial effects of silver nanoparticles have been explored in stable matrixes over the last decades. Interestingly, these nanoparticles present different action mechanisms when properties such as size, shape, and crystallographic structure are manipulated. This project aims to incorporate silver nanoparticles and indomethacin into polyamide 12 membranes to study the controlled release of the anti-inflammatory drug together with antimicrobial prevention. The membranes will be prepared by additive manufacturing in a partnership with Centro de Tecnologia e Informação Renato Archer. Then, the membranes will be pre-treated and functionalized with TEOS and APTES to promote better interaction between the silver nanoparticles and the drug. Kinetic studies will aid in understanding of the best concentration and time range for drug adsorption. The samples will also be subjected to antimicrobial tests to evaluate their efficiency against pathogens. The flexible membranes will be characterized by ultraviolet-visible and infrared spectrophotometry, X-ray diffractometric, and scanning electron microscopy. (AU)

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