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Histological analysis of doxycycline influence (SDD) in osteophenic rats, on the support periodonto, after orthodontic dental movement

Grant number: 19/13792-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2020
Field of knowledge:Health Sciences - Dentistry - Orthodontics
Principal Investigator:Maria Bernadete Sasso Stuani
Grantee:Luana Stefanie Silvino Gonçalves
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Closure of spaces caused by dental loss through orthodontically induced tooth movement, or even conventional orthodontic treatment, is a major challenge, especially in patients with osteoporosis. Objective: To evaluate the influence of doxycycline on bone remodeling, through the histological description of the degree of bone formation.Materials and Methods: Thirty - six Wistar rats will be used, which will be divided into 6 groups, the groups being defined as follows: C - Control; CDOX - Control exposed to doxycycline 30 mg/kg/day; CAL - Control exposed to sodium alendronate 0.7 mg/kg/ week; OVX - Ovariectomized Control; OVXDOX - Ovariectomy exposed to doxycycline 30 mg/kg/day; OVXAL - Ovariectomy exposed to alendronate sodium 0.7 mg/kg /week. Rats, about 80 days old, will undergo the osteopenia induction procedure for 90 days. After this period, the rats will be treated with doxycycline at a dose of 30 mg/kg/day or alendronate sodium at a dose of 0.7 mg/kg/week, both for 60 days. The total experimental period will be 150 days, and fourteen and seven days before the sacrifice will be mounted the orthodontic device for tooth movement. After 150 days of the start of the experiment, death will be induced. Samples of teeth submitted to orthodontic force will be submitted to histological analysis. Statistical analysis: The results of this project will be submitted to the multivariate linear model statistical test.

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