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Metabolomic analysis of the Caatinga molecular Chemiodiversity HPLC-MS-ESI based

Grant number: 19/16740-0
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): December 01, 2019
Effective date (End): January 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Norberto Peporine Lopes
Grantee:Danielle Rocha Pinho
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Caatinga is a Brazilian endemic biome that occupies 11% of the national territory, defined to the South by the Cerrado and to the East and West by the Atlantic and Amazon forests, respectively. Due to the increasing degradation of biological diversity resulting from anthropic actions, the understanding of this biome, limited as to its functioning, is fundamental for the maintenance of important ecosystem services as for the preservation of the genetic heritage of its biodiversity. Thus, considering the lack of knowledge about the chemical diversity of Caatinga, this project initially aims to contribute to the chemical-biological inventory of its biodiversity by acquiring metabolic fingerprints using fast and robust methodologies based on metabolomic studies using liquid chromatography high efficiency coupled with Mass Spectrometry (HPLC-MS). Also, to establish, through multivariate statistical tools, bioinformatics and the use of spectral similarity networks, investigations on the origin and distribution of metabolic patterns that help the understanding of the adaptive process to water stress suffered by Caatinga species. (AU)

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