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Exposure evaluation to pesticides, polycyclic aromatic hydrocarbons, and toxic elements in Brazilian children: establishment of reference values and possible association with oxidative stress biomarkers.

Grant number: 19/07161-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2020
Effective date (End): August 31, 2023
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Fernando Barbosa Júnior
Grantee:Marília Cristina Oliveira Souza
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):21/07994-8 - Determination of fifty-eight aromatic amines in textile products and assessment of pregnant women exposure, BE.EP.PD


The increase in agricultural demand and industrial production exposes the population to a large number of chemicals, including different classes of pesticides, polycyclic aromatic hydrocarbons (PAHs), and toxic elements, such as arsenic, cadmium, and mercury. Human biomonitoring (HB) allows the assessment of human exposure to different environmental contaminants by determining the contaminants themselves and/or their metabolites in biological matrices (mainly blood and urine). Children are a vulnerable subgroup of the population and the occurrence of adverse effects from exposure to environmental contaminants is potentiated by developmental, dietary, and physiological factors. Biomonitoring studies are often carried out in European countries, the United States and Canada. However, in Brazil, these studies are still scarce or absent. The occurrence of oxidative stress with DNA damage is an important mechanism of toxicity after the exposure to environmental contaminants, and it can be considered an important tool to the toxicity evaluation of different chemical stressors. The oxidative stress allows the formations of the DNA adduct, 8-hydroxy-2'-deoxyguanosine (8OH-DG) predominantly, that are formed by the oxidation of guanine at the C8 position. A variety of environmental contaminants have been reported as inducers of high levels of 8OH-DG. Considering the above, the evaluation of the exposure levels to pesticides, PAHs and toxic elements in children living in different regions of the country and the possible association with oxidative stress biomarkers, such as 8OHDG, is important for the future public policy actions in our country.

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Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; OLIVEIRA SOUZA, JULIANA MARIA; JACINTO SOUZA, JOAO CARLOS; BARBOSA, FERNANDO. Levels of polybrominated diphenyl ethers in Brazilian food of animal origin and estimation of human dietary exposure. Food and Chemical Toxicology, v. 150, . (15/19665-8, 19/07161-6, 18/24069-3)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; HERRERO, MARTA; MARQUES, MONTSE; ROVIRA, JOAQUIM; NADAL, MARTI; BARBOSA, FERNANDO; DOMINGO, JOSE LUIS. Screening of regulated aromatic amines in clothing marketed in Brazil and Spain: Assessment of human health risks. Environmental Research, v. 221, p. 10-pg., . (19/07161-6, 21/07994-8)
OLIVEIRA SOUZA, MARILIA CRISTINA; DEVOZ, PAULA PICOLI; BIANCHI XIMENEZ, JOAO PAULO; BOCATO, MARIANA ZUCCHERATO; ROCHA, BRUNO ALVES; BARBOSA, FERNANDO. Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 17, p. 11-pg., . (21/07994-8, 18/24069-3, 15/19665-8, 21/03633-0, 19/07161-6)
OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; ADEYEMI, JOSEPH A.; NADAL, MARTI; DOMINGO, JOSE LUIS; BARBOSA JR, FERNANDO. Legacy and emerging pollutants in Latin America: A critical review of occurrence and levels in environmental and food samples. Science of The Total Environment, v. 848, p. 29-pg., . (18/24069-3, 19/07161-6)
OLIVEIRA SOUZA, JULIANA MARIA; OLIVEIRA SOUZA, MARILIA CRISTINA; ALVES ROCHA, BRUNO; NADAL, MARTI; LUIS DOMINGO, JOSE; BARBOSA JR, FERNANDO. Levels of phthalates and bisphenol in toys from Brazilian markets: Migration rate into children's saliva and daily exposure. Science of The Total Environment, v. 828, p. 8-pg., . (18/24069-3, 15/19665-8, 14/24042-7, 19/07161-6)
CESILA, CIBELE APARECIDA; SOUZA, MARILIA CRISTINA OLIVEIRA; CRUZ, JONAS CARNEIRO; BOCATO, MARIANA ZUCCHERATO; CAMPIGLIA, ANDRES DOBAL; BARBOSA, FERNANDO. Biomonitoring of polycyclic aromatic hydrocarbons in Brazilian pregnant women: Urinary levels and health risk assessment. Environmental Research, v. 235, p. 10-pg., . (19/07161-6, 22/06443-0, 18/24069-3)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; ROVIRA, JOAQUIM; HERRERO, MARTA; MARQUES, MONTSE; NADAL, MARTI; BARBOSA JR, FERNANDO; DOMINGO, JOSE LUIS. Assessment of urinary aromatic amines in Brazilian pregnant women and association with DNA damage: Influence of genetic diversity, lifestyle, and environmental and socioeconomic factors. Environmental Pollution, v. 335, p. 8-pg., . (19/07161-6, 21/07994-8, 22/06443-0)
SOUZA, MARILIA CRISTINA OLIVEIRA; CRUZ, JONAS CARNEIRO; CESILA, CIBELE APARECIDA; GONZALEZ, NEUS; ROCHA, BRUNO ALVES; ADEYEMI, JOSEPH A.; NADAL, MARTI; DOMINGO, JOSE L.; BARBOSA, FERNANDO. Recent trends in pesticides in crops: A critical review of the duality of risks-benefits and the Brazilian legislation issue. Environmental Research, v. 228, p. 20-pg., . (19/07161-6, 21/07994-8)
SOUZA, MARILIA CRISTINA OLIVEIRA; GONZALEZ, NEUS; HERRERO, MARTA; MARQUES, MONTSE; ROVIRA, JOAQUIM; DOMINGO, JOSE L.; BARBOSA JR, FERNANDO; NADAL, MARTI. Non-regulated aromatic amines in clothing purchased in Spain and Brazil: Screening-level exposure and health impact assessment. Journal of Environmental Management, v. 339, p. 8-pg., . (19/07161-6, 21/07994-8, 18/24069-3)
SOUZA, MARILIA CRISTINA OLIVEIRA; ROCHA, BRUNO ALVES; CRUZ, JONAS CARNEIRO; PALIR, NEZA; CAMPIGLIA, ANDRES DOBAL; DOMINGO, JOSE L.; BARBOSA, FERNANDO. Risk characterization of human exposure to polycyclic aromatic hydrocarbons in vulnerable groups. Science of The Total Environment, v. 892, p. 6-pg., . (19/07161-6, 22/06443-0, 18/24069-3)
OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; BIANCHI XIMENEZ, JOAO PAULO; DEVOZ, PAULA PICOLI; SANTANA, ANTHONY; CAMPIGLIA, ANDRES DOBAL; BARBOSA JR, FERNANDO. Urinary levels of monohydroxylated polycyclic aromatic hydrocarbons in Brazilian children and health risk assessment: a human biomonitoring-based study. Environmental Science and Pollution Research, v. 29, n. 31, p. 12-pg., . (18/24069-3, 19/07161-6, 21/03633-0)
BARBOSA, FERNANDO; ROCHA, BRUNO A.; SOUZA, MARILIA C. O.; BOCATO, MARIANA Z.; AZEVEDO, LARA F.; ADEYEMI, JOSEPH A.; SANTANA, ANTHONY; CAMPIGLIA, ANDRES D.. Polycyclic aromatic hydrocarbons (PAHs): Updated aspects of their determination, kinetics in the human body, and toxicity. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, v. N/A, p. 38-pg., . (18/24069-3, 19/07161-6)

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