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Effect of the plasticizer bisphenol A (BPA) on the thyroid axis of adult teleost fish

Grant number: 19/23816-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): January 06, 2020
Effective date (End): March 22, 2020
Field of knowledge:Biological Sciences - Zoology - Physiology of Recent Groups
Principal Investigator:Renata Guimarães Moreira Whitton
Grantee:João Paulo Silva Pinheiro
Supervisor: Fabiana Laura Lo Nostro
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Universidad de Buenos Aires (UBA), Argentina  
Associated to the scholarship:16/08770-8 - Evaluation of the semen quality, mutagenicity and genotoxicity in Astyanax altiparanae (Teleostei, Characidae) exposed to aluminum in different water temperatures, BP.DR


Aquatic ecosystems can be strongly affected by anthropic activities resulting from agriculture, mining, industries and urban settlements. Among the released pollutants are the plasticizers (phthalates and bisphenols), that are considered of emerging concern. Bisphenol A (BPA) can involve disruption of multiple pathways related to several cellular and physiological processes (proliferation, metabolism, immune response, etc.) in both males and females. Thus, the main goal of the present project is to analyse the effects of the plasticizer BPA on the thyroid axis of adult teleost fish, with emphasis on the mode of action, and the possible interaction with the reproductive axis, using as a model a fish species representative of the Rio de la Plata basin, the cichlid fish Cichlasoma dimerus. The project will characterize the thyroid system of adult C. dimerus at the pituitary and thyroid gland levels and determine the mode of action of BPA on parameters of the thyroid and reproductive axis, using in vitro assays. (AU)

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