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Oncological safety of extraoral photobiomodulation in patients with oral and oropharyngeal squamous cell carcinoma

Grant number: 18/23479-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2019
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Alan Roger dos Santos Silva
Grantee:Elisa Kauark Fontes
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Aims: To assess, at clinical and molecular levels, the impact of prophylactic low-level laser therapy (photobiomodulation) for oral and oropharyngeal mucositis (OM) in the survival rates of patients with oral cavity and oropharyngeal squamous cell carcinoma (OSCC). Patients and Methods: 60 patients diagnosed with OSCC that will initiate curative protocols of adjuvant radiotherapy (RT) or chemoradiotherapy (CRT) will be prospectively assessed. Patients will be randomly allocated into two groups; Extraoral prophylactic photobiomodulation (n=30) (LED 69 diode, 34x660 nm (10 mW) and 35x850 nm (30 mW), 1390 mW, energy density 50 mW /cm2, 3.0J of energy/cm2, 60s/spot, spot size (6 cm2) and Placebo extraoral photobiomodulation sham laser (n=30). OM degree and OM associated pain will be assessed daily during the RT (NCI, Version 4.0, 2010; WHO, 1975 e VAS). The impact of the photobiomodulation will be evaluated quarterly during 18 months following RT conclusion, regarding the following oncological outcomes: local recurrences, development of second primary tumors, mean time of disease free survival and overall survival. Expected results: To contribute to a better understanding, in oncological terms, of the safety of photobiomodulation protocols regarding RT induced OM. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAUARK-FONTES, ELISA; RODRIGUES-OLIVEIRA, LETICIA; EPSTEIN, JOEL B.; FARIA, KARINA MORAIS; ARAUJO, ANNA LUIZA DAMACENO; GUEIROS, LUIZ ALCINO MONTEIRO; MIGLIORATI, CESAR AUGUSTO; SALLOUM, RAMZI G.; BURTON, PATRICIA; CARROLL, JAMES; et al. Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review. SUPPORTIVE CARE IN CANCER, v. 29, n. 6, . (18/02233-6, 18/23479-3)
RODRIGUES-OLIVEIRA, LETICIA; KAUARK-FONTES, ELISA; ALVES, CAROLINA GUIMARAES BONFIM; TONAKI, JULIANA ONO; GUEIROS, LUIZ ALCINO; MOUTINHO, KARINA; MARTA, GUSTAVO NADER; BARROS, LUCIANA RODRIGUES CARVALHO; SANTOS-SILVA, ALAN ROGER; BRANDAO, THAIS BIANCA; et al. COVID-19 impact on anxiety and depression in head and neck cancer patients: A cross-sectional study. ORAL DISEASES, v. 28, p. 9-pg., . (18/23479-3, 18/02233-6)
FARIA, KARINA MORAIS; GOMES-SILVA, WAGNER; KAUARK-FONTES, ELISA; BONFIM-ALVES, CAROLINA GUIMARAES; KOWALSKI, LUIZ PAULO; PRADO-RIBEIRO, ANA CAROLINA; VECHIATO-FILHO, ALJOMAR JOSE; LOPES, MARCIO AJUDARTE; MARTA, GUSTAVO NADER; DE CASTRO JR, GILBERTO; et al. Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy. SUPPORTIVE CARE IN CANCER, v. 28, n. 10, . (18/23479-3, 18/02233-6)
KAUARK-FONTES, ELISA; MIGLIORATI, CESAR AUGUSTO; EPSTEIN, JOEL B.; TREISTER, NATHANIEL SIMON; BONFIM ALVES, CAROLINA GUIMARAES; FARIA, KARINA MORAIS; PALMIER, NATALIA RANGEL; RODRIGUES-OLIVEIRA, LETICIA; PAGLIONI, MARIANA DE PAULI; MONTEIRO GUEIROS, LUIZ ALCINO; et al. Extraoral photobiomodulation for prevention of oral and oropharyngeal mucositis in head and neck cancer patients: interim analysis of a randomized, double-blind, clinical trial. SUPPORTIVE CARE IN CANCER, v. 30, n. 3, . (18/02233-6, 18/23479-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FONTES, Elisa Kauark. New perspectives for extraoral photobiomodulation in oral and oropharyngeal cancer patients. 2021. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.

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