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Development of biopolymeric wafers for buccal delivery of nanostructured drugs

Grant number: 19/08281-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2019
Effective date (End): August 31, 2021
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Laura de Oliveira Nascimento
Grantee:Renata de Carvalho Feitosa
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Exposure to bisphosphonates, antiangiogenic agents and radiotherapy may lead the dental patient to a medication-related osteonecrosis of the jaw (MRONJ). Bacterial infection plays an important role in the development of this disease; thus, oral formulations with antimicrobials may be prophylactic and therapeutic for such clinical condition. Nanotechnology can optimize the delivery of active substances, since nanoparticles (NPs) can increase bioavailability, reduce toxicity and release the drug in a modified and targeted fashion. However, there are barriers in the oral delivery of drugs through NPs, such as the washout caused by saliva; early degradation of NPs; release of the drug with burst effect and aggregation of the particles. Avoidance or attenuation of these drawbacks can be done by dispersing these NPs in micro or macro matrix (NP-in-matrix). These combined systems are still poorly explored in the literature but helpful for improving biopharmaceutical and pharmacokinetic aspects of formulations. Thus, this project comprises developing a NP-in-matrix system composed of biopolymeric oral wafers containing antibiotic-loaded chitosan nanoparticles and testing their potential antimicrobial activity in vitro. The formulations will be subjected to physical-chemical characterization, in vitro release/permeation profiles and in vitro antimicrobial activity against oral microorganisms. Besides the contribution as a potential alternative to prevent mandibular osteonecrosis, the formulations may be applied to other oral conditions caused by bacteria and contribute significantly to the knowledge about release kinetics of combined systems. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FEITOSA, RENATA CARVALHO; GERALDES, DANILO COSTA; BERALDO-DE-ARAUJO, VIVIANE LUCIA; RIBEIRO COSTA, JULIANA SOUZA; OLIVEIRA-NASCIMENTO, LAURA. Pharmacokinetic Aspects of Nanoparticle-in-Matrix Drug Delivery Systems for Oral/Buccal Delivery. FRONTIERS IN PHARMACOLOGY, v. 10, . (19/08281-5, 14/14457-5)
CARVALHO FEITOSA, RENATA; SOUZA RIBEIRO COSTA, JULIANA; VAN VLIET LIMA, MARCELO; SAWA AKIOKA ISHIKAWA, ELINA; COGO MULLER, KARINA; BONIN OKASAKI, FERNANDO; SABADINI, EDVALDO; GARNERO, CLAUDIA; LONGHI, MARCELA RAQUEL; LAVAYEN, VLADIMIR; et al. Supramolecular Arrangement of Doxycycline with Sulfobutylether-beta-Cyclodextrin: Impact on Nanostructuration with Chitosan, Drug Degradation and Antimicrobial Potency. PHARMACEUTICS, v. 15, n. 4, p. 18-pg., . (19/08281-5, 20/08059-8)
FEITOSA, RENATA CARVALHO; AKIOKA ISHIKAWA, ELINA SAWA; ALVES DA SILVA, MARIANA FARIAS; DA SILVA-JUNIOR, ARNOBIO ANTONIO; OLIVEIRA-NASCIMENTO, LAURA. Five decades of doxycycline: Does nanotechnology improve its properties?. International Journal of Pharmaceutics, v. 618, p. 16-pg., . (20/08059-8, 19/08281-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FEITOSA, Renata de Carvalho. Nanoestruturas para entrega modificada de doxiciclina: caracterização físico-química e microbiológica. 2021. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas Campinas, SP.

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