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Reducing sedentary time in bariatric patients: a randomized controlled trial

Grant number: 19/18039-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2019
Effective date (End): September 30, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Bruno Gualano
Grantee:Karla Fabiana Goessler
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study, AP.TEM

Abstract

This study aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behavior in specific clinical populations. To that end, we will perform three distinct randomized controlled trials and acute laboratorial studies involving rheumatoid arthritis, bariatric and mild cognitive impairment patients. All of these studies will be under the umbrella title Take a STAND for health, which also gives name to the intervention used in the randomized controlled trials to reduce sedentary behavior. The parallel-group randomized controlled trials aim to investigate the feasibility and efficacy of a newly developed personalized intervention focused on replacing sedentary time with light- (or very light-) intensity physical activity in these populations. A multitude of gold-standard techniques (thoroughly described in the next sections) will be applied to evaluate the effects of the intervention on several outcomes, including sedentary time (primary outcome), physical activity levels, clinical parameters specific to each condition, cardiometabolic risk factors (i.e., insulin sensitivity surrogates, lipid profile, inflammatory biomarkers, immune function, arterial blood pressure, autonomic function, body composition, and aerobic conditioning), and health-related quality of life. In addition, molecular analysis will be performed in both skeletal muscle and blood to gather knowledge on the possible mechanisms related to this intervention. The cross-over acute studies aim to unravel potential mechanisms underlying the effects of breaking up sedentary time with light-intensity physical activity versus carrying out the minimum amount of daily exercise at once and then remaining sedentary versus simply remaining sedentary throughout all sessions, in a well-controlled laboratorial condition. We will assess the physiological and metabolic parameters (i.e., arterial blood pressure, heart rate, insulin sensitivity surrogates, lipid profile, and inflammatory markers) throughout the experimental sessions. In addition, we will explore both skeletal muscle and blood molecular responses elicited by the interventions through targeted analyses of candidate genes and proteins potentially modulated by physical (in)activity as well as untargeted analyses, by means of proteomic and metabolomic approaches.

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCAL, ISABELA ROQUE; GOESSLER, KARLA FABIANA; BUYS, ROSELIEN; CASONATTO, JULIANO; CIOLAC, EMMANUEL GOMES; CORNELISSEN, VERONIQUE A.. Post-exercise Hypotension Following a Single Bout of High Intensity Interval Exercise vs. a Single Bout of Moderate Intensity Continuous Exercise in Adults With or Without Hypertension: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. FRONTIERS IN PHYSIOLOGY, v. 12, . (19/18039-7)
NICOLETTI, CAROLINA FERREIRA; ESTEVES, GABRIEL PERRI; GENARIO, RAFAEL; SANTO, MARCO AURELIO; DE CLEVA, ROBERTO; GUALANO, BRUNO; ROSCHEL, HAMILTON. Nutritional Inadequacies Among Post-bariatric Patients During COVID-19 Quarantine in Sao Paulo, Brazil. OBESITY SURGERY, v. 31, n. 5, . (20/07860-9, 19/18039-7, 15/26937-4, 17/13552-2)
MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA, v. 325, n. 11, . (20/11102-2, 15/26937-4, 17/13552-2, 19/24782-4, 19/18039-7, 20/05752-4, 16/00006-7)
LONGOBARDI, IGOR; GOESSLER, KARLA; DE OLIVEIRA JR, GERSIEL NASCIMENTO; DO PRADO, DANILO MARCELO LEITE; SANTOS, JHONNATAN VASCONCELOS PEREIRA; MELETTI, MATHEUS MOLINA; DE ANDRADE, DANIELI CASTRO OLIVEIRA; GIL, SAULO; BOZA, JOAO ANTONIO SPOTT DE OLIVEIRA; LIMA, FERNANDA RODRIGUES; et al. Effects of a 16-week home-based exercise training programme on health-related quality of life, functional capacity, and persistent symptoms in survivors of severe/critical COVID-19: a randomised controlled trial. BRITISH JOURNAL OF SPORTS MEDICINE, v. N/A, p. 10-pg., . (20/08091-9, 19/18039-7, 17/13552-2, 21/13580-1, 20/15678-6, 20/07540-4)
ESTEVES, GABRIEL P.; NOVELLI, FABIULA ISOTON; MELETTI, MATHEUS MOLINA; COSTA, LUIZ AUGUSTO RIANI; DO PRADO, DANILO MARCELO LEITE; MOLLER, GABRIELLA BERWIG; MARTICORENA, FELIPE MIGUEL; FRANCO, RUTH ROCHA; COMINATO, LOUISE; DOS SANTOS, CLAUDIA RENATA PINTO; et al. Cloth masks during exercise are safe and tolerable for children with overweight and obesity. PEDIATRIC PULMONOLOGY, v. 58, n. 7, p. 4-pg., . (21/05847-8, 19/18039-7, 17/13552-2, 20/07860-9, 20/15678-6)
REIS, BRUNA Z.; FERNANDES, ALAN L.; SALES, LUCAS P.; SANTOS, MAYARA D.; DOS SANTOS, CAROLINE C.; PINTO, ANA J.; GOESSLER, KARLA F.; FRANCO, ANDRE S.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; et al. Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 114, n. 2, p. 598-604, . (17/13552-2, 15/26937-4, 19/18039-7, 16/00006-7, 20/05752-4, 19/24782-4, 20/11102-2)
REZENDE, DIEGO A. N.; PINTO, ANA J.; GOESSLER, KARLA F.; NICOLETTI, CAROLINA F.; SIECZKOWSKA, SOFIA M.; MEIRELES, KAMILA; ESTEVES, GABRIEL P.; GENARIO, RAFAEL; OLIVEIRA JUNIOR, GERSIEL N.; SANTO, MARCO A.; et al. Influence of Adherence to Social Distancing Due to the COVID-19 Pandemic on Physical Activity Level in Post-bariatric Patients. OBESITY SURGERY, v. 31, n. 3, p. 1372-1375, . (19/15231-4, 17/13552-2, 15/26937-4, 19/18039-7)
PECANHA, TIAGO; GOESSLER, KARLA FABIANA; ROSCHEL, HAMILTON; GUALANO, BRUNO. Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 318, n. 6, p. H1441-H1446, . (17/13552-2, 19/07150-4, 19/18039-7)
GIL, SAULO; GOESSLER, KARLA; DANTAS, WAGNER S.; MURAI, IGOR HISASHI; MEREGE-FILHO, CARLOS ALBERTO ABUJABRA; PEREIRA, ROSA MARIA R.; DE CLEVA, ROBERTO; SANTO, MARCO AURELIO; KIRWAN, JOHN P.; ROSCHEL, HAMILTON; et al. Constraints of Weight Loss as a Marker of Bariatric Surgery Success: An Exploratory Study. FRONTIERS IN PHYSIOLOGY, v. 12, . (19/18039-7, 16/10993-5)
GOESSLER, KARLA FABIANA; NICOLETTI, CAROLINA FERREIRA; REZENDE, DIEGO AUGUSTO NUNES; SIECZKOWSKA, SOFIA MENDES; ESTEVES, GABRIEL PERRI; GENARIO, RAFAEL; DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NAKAHARA-MELO, MICHELE; et al. Outpatient Screening of Health Status Among Postbariatric Patients during the COVID-19 Pandemic in Sao Paulo, Brazil. OBESITY, v. 28, n. 12, p. 2263-2264, . (15/26937-4, 17/13552-2, 19/18039-7)
MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, v. 325, n. 11, p. 8-pg., . (20/11102-2, 16/00006-7, 19/24782-4, 15/26937-4, 19/18039-7, 20/05752-4, 17/13552-2)
DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; GOESSLER, KARLA FABIANA; PEREIRA SANTOS, JHONNATAN VASCONCELOS; DE LIMA, ALISSON PADILHA; GENARIO, RAFAEL; MEREGE-FILHO, CARLOS ALBERTO ABUJABRA; NUNES REZENDE, DIEGO AUGUSTO; DAMIOT, ANTHONY; DE CLEVA, ROBERTO; SANTO, MARCO AURELIO; et al. Home-Based Exercise Training During COVID-19 Pandemic in Post-Bariatric Patients: a Randomized Controlled Trial. OBESITY SURGERY, v. 31, n. 11, . (17/13552-2, 17/16104-0, 19/22160-6, 19/18039-7)
PINTO, ANA J.; GOESSLER, KARLA F.; FERNANDES, ALAN L.; MURAI, IGOR H.; SALES, LUCAS P.; REIS, BRUNA Z.; SANTOS, MAYARA DINIZ; ROSCHEL, HAMILTON; PEREIRA, ROSA M. R.; GUALANO, BRUNO. No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19. JOURNAL OF SPORT AND HEALTH SCIENCE, v. 10, n. 6, p. 690-696, . (16/00006-7, 20/05752-4, 15/26937-4, 19/18039-7, 19/24782-4, 17/13552-2, 20/11102-2)
FERNANDES, ALAN L.; MURAI, IGOR H.; REIS, BRUNA Z.; SALES, LUCAS P.; SANTOS, MAYARA D.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; et al. Effect of a single high dose of vitamin D-3 on cytokines, chemokines, and growth factor in patients with moderate to severe COVID-19. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 115, n. 3, p. 9-pg., . (20/11102-2, 19/18039-7, 19/24782-4, 20/05752-4)

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