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Morphological and functional characterization of long bone and perrimplant biomechanics in type 2 diabetic rats treated with resveratrol

Grant number: 19/19019-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2019
Effective date (End): September 30, 2021
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Roberta Okamoto
Grantee:Carolina Sayuri Wajima
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Type 2 diabetes (DM2) is responsible for 90% of diabetes cases worldwide, with obesity and an unhealthy lifestyle being its main risk factors. DM2 negatively influences the remodeling of long bones, increasing the risk of fractures and also in the oral cavity, delaying the bone repair process, and increasing the risk of infections. Resveratrol is a polyphenol that has hypoglycemic abilities and has a beneficial effect on bone tissue. The aim of this study will be to characterize, from the morphological and functional point of view, the long bones and periimplant biomechanics of normoglycemic and diabetic animals treated or not treated with resveratrol by biomechanics analysis (against tibial implant removal torque). computed microtomography in the distal portion of the femur and biomechanical assay. For this, 36 adult rats will be used, divided into 4 groups: CO (normoglycemic); COR (normoglycemic + resveratrol); DM2 (type 2 diabetics); DM2R (type 2 diabetics + resveratrol). Animals in the DM2 groups will have diabetes induced by a cafeteria diet for three weeks associated with a single application of streptozotocin (35mg / kg) dissolved in citrate buffer. Upon confirmation of type 2 diabetes, resveratrol treatment of the COR and DM2R animals will be initiated. After 15 days, an implant will be performed in the right tibial metaphysis of all animals. Euthanasia will be performed 30 days after implant placement, where biomechanical counter torque analysis will be performed on tibial implants, and the femurs will be removed for further computerized microtomography analysis of the distal portion and the mechanical assay. Quantitative data will be subjected to the normality test and this will indicate a more appropriate statistical test (parametric vs nonparametric). A significance level of 5% will be adopted for all tests. (AU)

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