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Evaluation of imiquimod penetration into skin and buccal mucosa before and after micronization using supercritical technology

Grant number: 19/19151-5
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): March 01, 2020
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Angela Maria Moraes
Grantee:Paula de Freitas Rosa Remiro
Supervisor: Sara Nicoli
Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Università degli Studi di Parma, Italy  
Associated to the scholarship:18/05237-2 - Micronization of the drug Imiquimode with supercritical CO2 aiming to increase the solubility in physiological media and its incorporation in new release vehicles, BP.PD


Drug bioavailability can be increased by numerous factors, among them the increase of its surface area. This parameter influences drug solubility in the matrices, allowing it to be more easily absorbed by the tissues. In this context, previous work was done with the aim of promoting the micronization of the anticancer drug imiquimod. After micronization of the drug, it is necessary to evaluate if, in fact, there was an increase in its bioavailability. Thus, this proposal aims to compare the drug penetration into the skin and buccal mucosa before and after the micronization process. For this, tests will be done ex vivo and the results will be used to characterize the way in which the drug penetrates on the studied tissues. Aqueous suspensions, hydrogels and films will be evaluated as drug delivery vehicles. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REMIRO, PAULA DE FREITAS ROSA; NAGAHARA, MARIANA HARUE TANIGUCHI; GHEZZI, MARTINA; FILIPPINI, ALESSIA; DEMURTAS, ANNA; PESCINA, SILVIA; SANTI, PATRIZIA; PADULA, CRISTINA; MORAES, ANGELA MARIA; NICOLI, SARA. An Alternative Device for the Topical Treatment of Oral Cancer: Development and Ex-Vivo Evaluation of Imiquimod-Loaded Polysaccharides Formulations. PHARMACEUTICS, v. 14, n. 12, p. 15-pg., . (19/19151-5, 18/05237-2)
GHEZZI, MARTINA; PESCINA, SILVIA; DELLEDONNE, ANDREA; FERRABOSCHI, ILARIA; SISSA, CRISTINA; TERENZIANI, FRANCESCA; REMIRO, PAULA DE FREITAS ROSA; SANTI, PATRIZIA; NICOLI, SARA. Improvement of Imiquimod Solubilization and Skin Retention via TPGS Micelles: Exploiting the Co-Solubilizing Effect of Oleic Acid. PHARMACEUTICS, v. 13, n. 9, . (19/19151-5)

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