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Potential evaluation of cetuximab-modified mesoporous silica nanoparticles as docetaxel carrier to prostate cancer treatment.

Grant number: 18/25377-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2020
Effective date (End): May 26, 2024
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Marlus Chorilli
Grantee:Rafael Miguel Sábio
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach, AP.TEM
Associated scholarship(s):22/02661-3 - Evaluation of cetuximab-modified porous silicon nanoparticles as docetaxel carrier to prostate cancer treatment, BE.EP.PD

Abstract

Prostate cancer (PC) is one of the most non-contagious diseases that affects the male population in the world. Although clinically effective, the chemotherapy treatment with docetaxel (DTX) is associated with the development of resistance in more advanced stages of the disease. Beyond that, DTX presents low aqueous solubility and drawbacks related to its pharmacokinetics. Mesoporous silica nanoparticles have attracted great interest due to their high chemical stability, large surface area and tunable pores diameters and volumes, allowing the incorporation of large amounts of drugs, protecting them from deactivation and degradation processes besides avoids premature release acting as an excellent nanocarrier. In addition, the hydroxyls groups available on its surface allows the conjugation of molecules such as the monoclonal antibody cetuximab (CTE) which binds to the overexpressed Enhanced Growth Factor Receptor (EGFR) in many prostate tumors, representing a potential strategy for the treatment of prostate cancer associated to DTX. Taking into account all aforementioned, the goal of this research project consist on develop intelligent nanoplatforms based on mesoporous silica nanoparticles functionalized with CTE as DTX carriers to PC treatment. This proposal aims to overcome drawbacks as low internalization, premature release before to reach the region of interest, several side effects to the patient and low effectiveness of the current treatments. In order to evaluate these parameters, materials characterization and methods validation will be carried out as well as in vitro assays using PC-3 and DU145 cells line models and in vivo assays from animal model aiming to prove the efficacy of the new nanocarriers.

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RICCIO, BRUNO VINCENZO FIOD; DO NASCIMENTO, ANDRE LUIZ CARNEIRO SOARES; MENEGUIN, ANDREIA BAGLIOTTI; RODERO, CAMILA FERNANDA; SANTOS, KAIO PINI; SABIO, RAFAEL MIGUEL; DE ANNUNZIO, SARAH RAQUEL; FONTANA, CARLA RAQUEL; BARUD, HERNANE DA SILVA; FERRARI, PRISCILEILA COLERATO; et al. Solid Dispersions Incorporated into PVP Films for the Controlled Release of Trans-Resveratrol: Development, Physicochemical and In Vitro Characterizations and In Vivo Cutaneous Anti-Inflammatory Evaluation. PHARMACEUTICS, v. 14, n. 6, p. 21-pg., . (19/19817-3, 18/09088-1, 18/23015-7, 18/25377-3, 18/23357-5, 19/00164-0)
RIBEIRO, TAIS C.; SABIO, RAFAEL M.; CARVALHO, GABRIELA C.; FONSECA-SANTOS, BRUNO; CHORILLI, MARLUS. Exploiting mesoporous silica, silver and gold nanoparticles for neurodegenerative diseases treatment. International Journal of Pharmaceutics, v. 624, p. 16-pg., . (19/26821-7, 19/19228-8, 18/25377-3)
SABIO, RAFAEL MIGUEL; MENEGUIN, ANDREIA BAGLIOTTI; DOS SANTOS, ALINE MARTINS; MONTEIRO, ANDREIA SOFIA; CHORILLI, MARLUS. Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration. Microporous and Mesoporous Materials, v. 312, . (18/25377-3, 14/50928-2)
CARVALHO, GABRIELA CORREA; MARENA, GABRIEL DAVI; FISCHER KARNOPP, JULIANA CAMILA; JORGE, JULIANA; SABIO, RAFAEL MIGUEL; UTRERA MARTINES, MARCO ANTONIO; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Cetyltrimethylammonium bromide in the synthesis of mesoporous silica nanoparticles: General aspects and in vitro toxicity. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 307, p. 14-pg., . (19/26821-7, 18/25377-3, 19/09831-9)
CARVALHO, GABRIELA CORREA; MARENA, GABRIEL DAVI; LEONARDI, GABRIELA RICCI; SABIO, RAFAEL MIGUEL; CORREA, IONE; CHORILLI, MARLUS; BAUAB, TAIS MARIA. Lycopene, Mesoporous Silica Nanoparticles and Their Association: A Possible Alternative against Vulvovaginal Candidiasis?. Molecules, v. 27, n. 23, p. 13-pg., . (19/26821-7, 18/25377-3, 19/09831-9)
MARENA, GABRIEL DAVI; DOS SANTOS RAMOS, MATHEUS APARECIDO; CARVALHO, GABRIELA CORREA; DE LIMA, LAURA CAMINITTI; CARNEIRO SOARES DO NASCIMENTO, ANDRE LUIZ; SABIO, RAFAEL MIGUEL; RODERO, CAMILA FERNANDA; SPOSITO, LARISSA; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Development and characterization of an amphotericin B - loaded nanoemulsion applied to Candida auris biofilms control. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 74, p. 14-pg., . (19/26821-7, 18/25377-3, 19/09597-6, 19/09831-9, 18/23442-2, 14/50928-2, 17/22758-3, 18/23357-5)
RIBEIRO, TAIS DE CASSIA; SABIO, RAFAEL MIGUEL; LUIZ, MARCELA TAVARES; DE SOUZA, LUCAS CANTO; FONSECA-SANTOS, BRUNO; CIDES DA SILVA, LUIS CARLOS; DE ABREU FANTINI, MARCIA CARVALHO; PLANETA, CLEOPATRA DA SILVA; CHORILLI, MARLUS. Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy. PHARMACEUTICS, v. 14, n. 9, p. 19-pg., . (19/19228-8, 18/25377-3, 14/50928-2)
CARVALHO, GABRIELA CORREA; SABIO, RAFAEL MIGUEL; SPOSITO, LARISSA; ANDREOLI PINTO, TEREZINHA DE JESUS; CHORILLI, MARLUS. An overview of the use of central venous catheters impregnated with drugs or with inorganic nanoparticles as a strategy in preventing infections. International Journal of Pharmaceutics, v. 615, p. 12-pg., . (19/26821-7, 18/25377-3)

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