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Tuning MFe2O4 (M=Co,Ni) nanoparticles for in vivo biomedical applications: Doping with rare earths and biocompatible coating

Grant number: 19/15620-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2019
Effective date (End): March 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:Artur Wilson Carbonari
Grantee:Anastasia Nikolaevna Burimova
Host Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:17/50332-0 - Scientific, technological and infrastructure qualification in radiopharmaceuticals, radiation and entrepreneurship for health purposes (PDIp), AP.PDIP


This project aims at fabrication of biocompatible magnetic nanoparticles on cobalt or nickel ferrite basis with a potential to adapt them for radiotherapy among other medical applications. Organic coating is expected to provide the biocompatibility of (Ni,Co)Fe2O4, whereas doping elements, RE=Sm, Eu, Gd, Er, are believed to enhance radiotherapeutic efficiency. We intend to adapt synthesis procedure to reach desired morphology and ensemble characteristics, thus tuning the overall properties of the particles for desired applications. Two novelties will be developed in this work plan, the incorporation of radioisotopes to the nanoparticles, in thiscase the 111In, allowing their tracking and the investigation of the chemical bond stability ofthis radioisotope to the nanoparticle and, second, the study of the dynamical behavior of the particles in liquid solutions, simulating their environment in medical applications.

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALES, T. S. N.; BURIMOVA, A.; RODRIGUES, P. S.; MATOS, I. T.; CABRERA-PASCA, G. A.; SAXENA, R. N.; PEREIRA, L. F. D.; OTUBO, L.; CARBONARI, A. W.. Synthesis and characterization of Fe3O4-HfO2 nanoparticles by hyperfine interactions measurements. AIP ADVANCES, v. 11, n. 1, . (19/15620-0, 17/50332-0)
MACIEL, L. S.; BURIMOVA, A.; PEREIRA, L. F. D.; FERREIRA, W. L.; SALES, T. S. N.; GONCALVES, V. C.; CABRERA-PASCA, G. A.; SAXENA, R. N.; CARBONARI, A. W.. DFT-based calculations of the magnetic hyperfine interactions at Cd sites in RCd (R = rare earth) compounds with the FP-LAPW ELK code. AIP ADVANCES, v. 11, n. 2, . (19/15620-0)
CABRERA-PASCA, G. A.; MAGNO, J. F.; FERREIRA, W. L.; CAMPOS, A. C.; BOSCH-SANTOS, B.; SALES, T. S. N.; PEREIRA, L. F. D.; BURIMOVA, A.; SAXENA, R. N.; FREITAS, R. S.; et al. Local inspection of magnetic properties in GdMnIn by measuring hyperfine interactions. AIP ADVANCES, v. 11, n. 1, . (19/15620-0)
CABRERA-PASCA, G. A.; BOSCH-SANTOS, B.; BURIMOVA, A. N.; CORREA, E. L.; CARBONARI, A. W.. Effect of the magnetic impurity on the charge diffusion in highly dilute Ce doped LaMnO3. AIP ADVANCES, v. 10, n. 1, . (19/15620-0, 14/14001-1)
BURIMOVA, ANASTASIA; CARBONARI, ARTUR WILSON; DE LIMA, NICOLE PEREIRA; MIRANDA FILHO, ARNALDO ALVES; DOS SANTOS SOUZA, ALEXANDRE PINHO; NASCIMENTO SALES, TATIANE DA SILVA; FERREIRA, WANDERSON LOBATO; DIAS PEREIRA, LUCIANO FABRICIO; CORREA, BRUNO SANTOS; SAXENA, RAJENDRA NARAIN. Local Crystalline Structure of Doped Semiconductor Oxides Characterized by Perturbed Angular Correlations: Experimental and Theoretical Insights. CRYSTALS, v. 12, n. 9, p. 15-pg., . (18/18657-0, 19/15620-0, 17/50332-0)
SANTOS, V, RENATA; CABRERA-PASCA, GABRIEL A.; COSTA, CLEIDILANE S.; BOSCH-SANTOS, BRIANNA; OTUBO, LARISSA; PEREIRA, LUCIANO F. D.; CORREA, BRUNO S.; EFFENBERGER, FERNANDO B.; BURIMOVA, ANASTASIA; FREITAS, RAFAEL S.; et al. Crystalline and magnetic properties of CoO nanoparticles locally investigated by using radioactive indium tracer. SCIENTIFIC REPORTS, v. 11, n. 1, . (19/15620-0, 17/50332-0, 15/16191-5)
RODRIGUES, PRISCILA S.; BURIMOVA, ANASTASIA; SALES, TATIANE S. N.; FILHO, ARNALDO A. M.; OTUBO, LARISSA; SAXENA, RAJENDRA N.; CARBONARI, ARTUR W.. The effect of Er doping on local structure of magnetite nanoparticles. HYPERFINE INTERACTIONS, v. 242, n. 1, p. 6-pg., . (19/15620-0, 17/50332-0)

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