Advanced search
Start date

Role of intravascular hemolysis on Priapism in transgenic sickle cell mice: therapeutic potential of haptoglobin

Grant number: 19/17030-6
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2019
Effective date (End): November 30, 2021
Field of knowledge:Biological Sciences - Pharmacology - Autonomic Pharmacology
Principal researcher:Fábio Henrique da Silva
Grantee:Pamela da Silva Pereira
Home Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:17/08122-9 - Priapism and voiding dysfunction in Sickle Cell Disease: pathophysiology and new drug candidates, AP.JP


In sickle cell anemia, intravascular hemolysis results in the release of hemoglobin to plasma. Under physiological conditions, haptoglobin is the plasma protein responsible for the body's defense against free hemoglobin accumulation. In plasma, haptoglobin binds to free hemoglobin and this complex is metabolized by macrophages in the reticuloendothelial system. However, in sickle cell anemia, high hemoglobin concentrations are released into plasma, saturating haptoglobin, and thus accumulating free hemoglobin in plasma. In plasma or interstitial space, hemoglobin reacts to nitric oxide (NO), generating nitrat and metahemoglobin. Reduced penile NO bioavailability has been identified as one of the main causes for triggering priapism in men with sickle cell anemia and mice transgenic sickle cell. Clinical studies have showed a strong positive correlation between priapism and high levels of intravascular hemolysis in men with sickle cell anemia. However, no study has evaluated the effect of intravascular hemolysis on erectile function in transgenic mice for sickle cell anemia. In the present study, we hypothesized that the reduction of NO bioavailability by hemoglobin in the penis contributes to priapism in sickle cell anemia. Thus, we propose to study the role of intravascular hemolysis in priapism in transgenic sickle cell mice and in C57BL/6 mice with phenylidrazine-induced intravascular hemolysis. It also aims to evaluate the effect of haptoglobin treatment on priapism in sickle cell anemia. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: