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Identification of bioactive compounds from Pitanga do Cerrado (Eugenia calycina Cambess) and study of its biological activities

Grant number: 18/10608-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2019
Effective date (End): April 30, 2022
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal researcher:Glaucia Maria Pastore
Grantee:Nayara Macedo Peixoto
Home Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):19/27103-0 - Evaluation of the bioactive potential of flavonoids properties from Eugenia calycina Cambess, BE.EP.DR

Abstract

The present project aiming to cover the phenolic composition and the potential biological properties of pitanga (Eugenia calycina Cambess) berry from Cerrado, an unknown and underexplored Brazilian fruit. Firstly, we will study the extraction of phenolic compounds from different parts (pulp, leaves and seeds) of pitanga using emergent extraction technologies, namely Pressurized Liquid Extraction (PLE), Ultrasonic Assisted Extraction (UAE), and the combinations thereof (UAE + PLE). The composition and concentration of phenolic compounds (flavonoids and phenolic acids) from pitanga extracts will be evaluated using UHPLC-Q-TOF-MS and HPLC-ESI-MS/MS. The capacity of secondary metabolites, mainly phenolic compounds, of scavenging free radicals, reducing oxidative stress, and preventing biomolecules oxidation have been strongly associated with the reduce of the risk of diabetic and cancer, and as wound healing compounds. In this approach, the antioxidant, antidiabetic, antiproliferative and wound healing activities will be investigated. The antioxidant activity will be evaluated using hydrogen atom transfer mechanisms, such as ORAC assay (Oxygen Radical Absorbance Capacity). The pitanga extracts will be used as inhibitors of digestive enzymes, such as ±-amylase and ±-glycosidase, to verify their potential antidiabetic activity. Finally, the antiproliferative effect of pitanga extracts will be investigated on ten human tumor cell lines, namely glioma (U251), breast (MCF-7), multidrug resistant ovary carcinoma (NCI-ADR/RES), kidney (786-0), non-small cell lung cancer (NCI-H460), prostate (PC-3), colon adenocarcinoma (HT-29), leukemia (K562), melanoma (UACC-62), and ovarian (OVCAR-3), and the scratch assay will be used to evaluate the wound healing properties of pitanga. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARAUJO, NAYARA MACEDO PEIXOTO; SILVA, ERIC KEVEN; ARRUDA, HENRIQUE SILVANO; DE MORAIS, DAMILA RODRIGUES; MEIRELES, MARIA ANGELA A.; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA. ecovering phenolic compounds from Eugenia calycina Cambess employing high-intensity ultrasound treatments: A comparison among its leaves, fruit pulp, and seed as promising sources of bioactive compound. Separation and Purification Technology, v. 272, OCT 1 2021. Web of Science Citations: 2.
ARAUJO, NAYARA MACEDO PEIXOTO; ARRUDA, HENRIQUE SILVANO; MARQUES, DAVID ROGER PAIXAO; OLIVEIRA, WILLIARA QUEIROZ DE; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA. Functional and nutritional properties of selected Amazon fruits: A review. Food Research International, v. 147, SEP 2021. Web of Science Citations: 0.
ARRUDA, HENRIQUE SILVANO; SILVA, ERIC KEVEN; PEIXOTO ARAUJO, NAYARA MACEDO; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA; MAROSTICA JUNIOR, MARIO ROBERTO. Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems. Molecules, v. 26, n. 9 MAY 2021. Web of Science Citations: 1.
ARAUJO, NAYARA MACEDO PEIXOTO; ARRUDA, HENRIQUE SILVANO; FARIAS, DAVID DE PAULO; MOLINA, GUSTAVO; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA. Plants from the genus Eugenia as promising therapeutic agents for the management of diabetes mellitus: A review. Food Research International, v. 142, APR 2021. Web of Science Citations: 0.
PEIXOTO ARAUJO, NAYARA MACEDO; ARRUDA, HENRIQUE SILVANO; DOS SANTOS, FABIO NEVES; DE MORAIS, DAMILA RODRIGUES; PEREIRA, GUSTAVO ARAUJO; PASTORE, GLAUCIA MARIA. LC-MS/MS screening and identification of bioactive compounds in leaves, pulp and seed from Eugenia calycina Cambess. Food Research International, v. 137, NOV 2020. Web of Science Citations: 2.
PRADO, LIVIA GARCIA; ARRUDA, HENRIQUE SILVANO; PEIXOTO ARAUJO, NAYARA MACEDO; DE OLIVEIRA BRAGA, LUCIA ELAINE; BANZATO, THAIS PETROCHELLI; PEREIRA, GUSTAVO ARAUJO; FIGUEIREDO, MARIANA CECCHETTO; TASCA GOIS RUIZ, ANA LUCIA; EBERLIN, MARCOS NOGUEIRA; DE CARVALHO, JOAO ERNESTO; VENDRAMINI-COSTA, DEBORA BARBOSA; PASTORE, GLAUCIA MARIA. Antioxidant, antiproliferative and healing properties of araticum (Annona crassiflora Mart.) peel and seed. Food Research International, v. 133, JUL 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.