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Evaluation of the inflammatory response in peripheral blood mononuclear cells of sedentary individuals: role of physical exercise and capsaicin

Grant number: 19/11340-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2019
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Fábio Santos de Lira
Grantee:Tiago Olean Oliveira
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


Physical inactivity associated with poor eating habits is associated with excessive accumulation of visceral adipose tissue and chronic low-grade inflammation. Adoption of non-pharmacological strategies that potentiate the energy expenditure that leads to reduction of adipose tissue stores, especially visceral fat deposition and reduction in pro-inflammatory cytokine concentrations. We hypothesized that the adoption of the high-intensity interval training (HIIT) associated with the daily intake of the bioactive compounds of pepper popularly known as capsaicin (capsiate) promote protective effects through the reduction of body fat and modulation of inflammatory response of peripheral blood mononuclear cells. The objective of the present study will be to evaluate the effect of HIIT associated with capsaicin supplementation on body composition and inflammatory response of peripheral blood mononuclear cells (PBMC). The experimental design of the study will be double-blind placebo controlled. Participants will perform 12 weeks of HIIT, 3x per week. A maximum incremental test will be performed on the treadmill to quantify the maximum oxygen consumption (VO2max), body evaluation will be by DEXA and visceral fat by ultrasonography. Blood samples collected at rest for biochemical and cytokine analyzes. The PBMCs will be isolated and stimulated in vitro LPS and Concacavalin A, in the presence or absence of capsaicin and capsiate, evaluating the production of cytokines in the culture medium, and gene expression of inflammatory proteins in the PBMC after 48h of treatment in the different training periods physicist. For statistical treatment, a two-way Shapiro-Wilk test and analysis of variance will be performed to compare moments (pre and post intervention), analyzed by SPSS software (version 22.0). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLEAN-OLIVEIRA, TIAGO; FIGUEIREDO, CAIQUE; DE POLI, RODRIGO ARAUJO BONETTI; LOPES, VITHOR HUGO FIALHO; JIMENEZ-MALDONADO, ALBERTO; LIRA, FABIO SANTOS; ANTUNES, BARBARA MOURA. Menstrual cycle impacts adipokine and lipoprotein responses to acute high-intensity intermittent exercise bout. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 122, n. 1, . (19/26378-6, 19/22726-0, 19/17445-1, 19/11340-3, 19/25282-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Tiago Olean. Evaluation of the inflammatory response in peripheral blood mononuclear cells of young adults with different body compositions and physical aptitudes: role of capsaicin and adrenergic receptors. 2022. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.

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