Proposal of a research internship with Harvard University (School of Public Health) between November 2019 - February 2020 under the supervision of Professor Dr. Edward Giovannucci. We aim to learn about Nutritional Epidemiology and the statistical analyses for validity of dietary assessment methods (the goal of the Ph.D. scholarship in Brazil), contextualizing the peculiarities related to the biomarkers used for this validity, in particular, the vitamin A. In addition, we also aim to improve our scientific qualification in several aspects, such as the writing of the systematic review and learning with the research group in courses, seminars, and other scientific studies. Objective: To systematically review the scientific literature about the opportunities/challenges for the development of blood vitamin A reference values in children. Methods: We will search the Medline, Web of Science, Embase and Central databases, using the descriptors: children; vitamin A; retinol; beta-carotene; anemia; xerophthalmia; immune function; bone fracture; impaired growth; mortality. We pretend to establish a critical level between blood concentrations of retinol and beta-carotene and dietary intake of vitamin A. If the within-population variance of vitamin A intake is constant across populations (that varied by vitamin A status), the mean of the distribution will be relocated over the cutoff point for a biomarker/clinical outcome, thus used to estimate the cutoff point for blood vitamin A (retinol and beta-carotene). We hope the findings from this project can help to inform a reliable vitamin A reference value in blood for children.
News published in Agência FAPESP Newsletter about the scholarship: