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Zika Virus Irreversible Inactivation by Dendritic Copolymers as Broad-Spectrum Antiviral Agents

Grant number: 19/17028-1
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): October 28, 2019
Effective date (End): October 27, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Mateus Borba Cardoso
Grantee:Lívia Mesquita Dias Loiola
Supervisor abroad: Alexander N. Zelikin
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovações (Brasil). Campinas , SP, Brazil
Research place: Aarhus University, Denmark  
Associated to the scholarship:16/21598-0 - Functionalized silica nanoparticles: a strategy for Zika virus inactivation, BP.PD

Abstract

Besides significant advances in the last centuries, humanity still suffer from a plenty of viral diseases for which we have no vaccines or specific treatments. Development of prevention or treatment measures for emerging viral diseases has been proven difficult and expensive. The solution to this problem may reside in molecules that are broadly active, protective against different viruses, also known as broad-spectrum antiviral agents. Herein we propose the development of dendritic polyanions-based materials, that may act as virustatic polymers ultimate leading to virus irreversible distortion, as a consequence of the multivalent bind to viruses particles. The predicted permanent virus inactivation response of the designed dendritic polymers, specially focused on Brazilian ZIKV, would make them virucidal therapeutic strategies against viral infections in humans.

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