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Effect of probiotic adjuvant therapy (Lactobacillus reuteri) in diabetics patients with periodontitis using the PISA index

Grant number: 19/14344-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2020
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Maria Aparecida Neves Jardini
Grantee:Luana Reis Silva
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


The association of probiotics with mechanical debridement has been proposed for the treatment of periodontal diseases, but this effect has not yet been evaluated in patients with type 2 diabetes mellitus (DM2). Being the main objective of periodontal therapy associated or not to adjuvants reduce the inflammation and the restoration of a tissue homeostasis, is this et al. in 2008, proposed an index, called PISA, to evaluate an area and inflamed tissue. On the other hand, it is also important to analyze how dental care impacts on the quality of life of individuals. Among several instruments to measure the quality of life of oral health, Oral Health Impact Profile (OHIP-14) (Slade 97) has been shown to be efficient through the evaluation of associations with sociodemographic and clinical variables with oral status. The objective of this randomized, triple-blind, controlled clinical trial will be to evaluate the effects of probiotic administration (Lactobacillus reuteri) as adjunctive therapy in the treatment of periodontitis associated with T2DM. Patients will also respond to the OHIP questionnaire 14 on quality of life. Participants will be randomized into 2 groups: Test Group (n = 20): Patients with periodontitis and patients with DM2 who will receive periodontal debridement associated with the probiotic Lactobacillus reuteri; and Control Group (n = 20): patients with Periodontitis and patients with DM2, treated with periodontal debridement associated with a placebo. The results obtained before and after the periodontal therapy will be analyzed through the Shapiro-wilk and Chi-Square test.

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