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"dereplication", sequencing and identification of peptides from brazilian plants: a new approach to chemical ecology

Grant number: 18/24894-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2019
Effective date (End): August 31, 2021
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Vanderlan da Silva Bolzani
Grantee:Nathalia Baptista Dias
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Brazil has one of the largest biodiversity in the world, being a highly sophisticated laboratory of diverse and unique molecular models, constituting a rich source of molecules with structural characteristics and interesting ecological and pharmacological functions. Biologically active natural peptides have attracted the attention of researchers and industry, both from a clinical and biotechnological point of view. Several peptides with insecticidal, antimicrobial, antifungal and anticancer properties have already been isolated. Despite this great potential, a still limited number of peptides derived from Brazilian plants have been studied and deposited in open access banks. The present project aims to standardize and study the peptide complexity of different plant species (Jatropha ribifolia, Jatropha gossypifolia, Jatropha molíssima, Pombalia calceolaria and Viola cerasifolia) by separating and sequencing online by LCMS / MSn, in order to construct Brazilian plant peptide libraries (linear, orbit, and cyclotubes) characteristic for each species under study, which will be available to the scientific community through the deposition of spectra in molecular networks. This work also aims at the international collaboration in a laboratory recognized worldwide and specialized in NMR of peptides for the determination of three-dimensional structures of the peptides identified that are interesting from the biotechnological point of view.

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