Introduction: Understanding the evolution of neonatal mortality through the analysis of its temporal and geographical distribution can contribute to the design of interventions that facilitate the achievement of the Sustainable Development Goals established in 2015 by the UN. Objective: To analyze the spatial evolution of neonatal mortality due to prematurity, respiratory disorders, perinatal asphyxia, infections and congenital anomalies in the state of São Paulo between 2002 and 2015. Method: A population cohort study of live births between 2002-2015 in the State of São Paulo classified into two groups: those who died between 0-27 days and those who were alive until the 27th day of life (estimated: 8,400,000 births and 75,000 neonatal deaths). For the deaths, the data will come from the linkage of SEADE Foundation databases collected from birth and death certificates. Spatial analysis will be applied to verify the existence of non-random patterns in geographic space units of the State of São Paulo in the course of time according to the cause of death (prematurity, respiratory distress, perinatal asphyxia, infections and congenital anomalies) and the age of death (1st hour, 24 hours, 0-6 days and 7-27 days after birth).
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