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Topical delivery of endoxifene and celecoxib using nanogels as a new alternative for the chemoprevention of breast tumors

Grant number: 19/00196-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2019
Effective date (End): January 31, 2021
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Luciana Biagini Lopes
Grantee:Gabriela Mojeiko
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/16617-7 - Nanostructured systems for topical delivery and co-localization of chemopreventive and chemoterapeutic agents in the skin and breast tissue, AP.JP

Abstract

Breast cancer is currently the most common neoplasm in women worldwide, but there are few alternatives for its prevention, a factor that must be prioritized for disease control. In this project, we propose the development of topical nanogels for the self-administration of the combination of celecoxib and endoxifene, in order to optimize deep skin penetration and localization of drugs in breast tissue as a new strategy for the chemoprevention of breast cancer. Lamellar phase nanogels and nanoemulsions will be developed using a mixture of surfactants composed of soy phosphatidylcholine and glycerol, and the oil phase will be comprised of tricaprilin, monocaprilin and Shea or passion fruit butter. The relationship between composition, type phase formed and incorporation of the drug will be evaluated. Subsequently, selected formulations will be characterized, and evaluated for to their ability to promote penetration into the skin. Assays using the HET-CAM model will be used to estimate the potential irritation of the formulation on the skin, while the cytotoxic effect of the drugs incorporated into the nanocarrier will be evaluated in MCF-7 cells using the MTT method. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOJEIKO, GABRIELA; PASSOS, JULIA SAPIENZA; APOLINARIO, ALEXSANDRA CONCEICAO; LOPES, LUCIANA BIAGINI. opical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us. Nanomedicine, v. 16, n. 19, . (18/13877-1, 18/14375-0, 19/00196-9, 20/01208-8, 14/50928-2)
MOJEIKO, GABRIELA; APOLINARIO, ALEXSANDRA CONCEICA; SALATA, GIOVANNA CASSONE; CHORILLI, MARLUS; LOPES, LUCIANA B.. Optimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 646, p. 14-pg., . (19/26048-6, 18/14375-0, 19/00196-9, 18/13877-1, 14/50928-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MOJEIKO, Gabriela. Topical delivery of endoxifene and celecoxib using nanocarriers as a new alternative for breast cancer prevention.. 2021. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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Filed patent(s) as a result of this research project

NANOFORMULAÇÃO EM GEL POLIMÉRICO ETOSSOMAL E SEU USO NA PREPARAÇÃO DE UM MEDICAMENTO PARA A QUIMIOPREVENÇÃO DO CÂNCER DE MAMA E NA PREVENÇÃO E/OU TRATAMENTO DO CÂNCER DE PELE E CERVICAL BR1020210221771 - Universidade de São Paulo (USP) . LUCIANA BIAGINI LOPES, GIOVANNA CASSONE SALATA, ALEXSANDRA CONCEIÇÃO APOLINÁRIO, GABRIELA MOJEIKO - November 2021, 04