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Physicochemical characterization and biological analyses of two different methods for functionalization of Ti-15Mo alloy surface with strontium

Grant number: 19/10463-4
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): August 01, 2019
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Joni Augusto Cirelli
Grantee:Flavia Gomes Matos
Supervisor: Morten Foss
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Aarhus University, Denmark  
Associated to the scholarship:18/09256-1 - Biological evaluation and physicochemical properties of the surface of Titanium-15Mo submitted to hydrothermal treatment with strontium. in vitro study, BP.MS


Surface treatments, development of new alloys and functionalization of implant surfaces with bioactive elements have been the objective of recent studies in the area of implant dentistry aiming to contribute to the process of osseointegration. The functionalization of the titanium surface with strontium can be performed by different methods. The purpose of this study is to compare, in vitro, disks of titanium-15-molybdenum alloy submitted to two different strontium (Sr) application processes: 1) the magnetron co-sputtering method used by the Aarhus University study group and 2) the hydrothermal method used by the FOAr-Unesp group. The surfaces will be evaluated for topography by scanning electron microscopy tests, chemical composition through X-ray photoelectron spectroscopy tests and Sr release profiles will be investigated by wash-out experiments. In addition, the response of Periodontal ligament cells (PDLCs) to these surfaces will be evaluated by observing cell morphology, adhesion, proliferation and cytotoxicity. These results are expected to determine benefits and possible applications of this new surface treatment in Implantology. (AU)

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