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Translational cancer epidemiology: a study of physical activity and cancer prevention

Grant number: 18/23941-9
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2019
Effective date (End): July 30, 2019
Field of knowledge:Health Sciences - Collective Health - Epidemiology
Principal Investigator:José Eluf Neto
Grantee:Leandro Fórnias Machado de Rezende
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The objectives of this post-doctoral project are (1) to estimate the effect of different types, intensities and periods of life of physical activity on the risk of cancer; (2) to evaluate the costs of the Brazilian public health system with the treatment of cancers that could potentially be saved by increasing physical activity. For the first objective of the project, we will use data from the Harvard cohorts (Nurses' Health Study, Nurses' Health Study II and Health Professionals Follow-up Study) that included approximately 300,000 participants. The follow-up has been conducted through questionnaires on nutrition, lifestyle, physical activity, and different health outcomes. Diagnosis of cancer (by anatomical location, stage and histological type) are obtained via medical and pathological records. We will analyze the associations of different types (aerobic versus muscular strength), intensities (sedentary, light, moderate and vigorous) and life periods (12-13, 14-17, 17-22, 23-29, 30-34, e35 years of age) of physical activity with cancer risk through Cox regression models. For the second objective, we will use information from (i) 57,962 adults who answered the physical activity questionnaire in the Brazilian National Health Survey; (ii) estimates of RR of cancer from a meta-analysis; (iii) hospitalization costs, chemotherapy and radiotherapy procedures from the Hospital Information System of the Unified Health System and the APAC System. We will estimate costs with cancer treatment that could potentially be saved by increasing physical activity using the population attributable fraction method.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REZENDE, LEANDRO F. M.; LEE, DONG HOON; KEUM, NANA; WU, KANA; ELUF-NETO, JOSE; TABUNG, FRED K.; GIOVANNUCCI, EDWARD L.. Resistance training and total and site-specific cancer risk: a prospective cohort study of 33,787 US men. BRITISH JOURNAL OF CANCER, v. 123, n. 4, . (18/23941-9)
REZENDE, LEANDRO F. M.; LEE, DONG HOON; FERRARI, GERSON; ELUF-NETO, JOSE; GIOVANNUCCI, EDWARD L.. Physical activity for cancer patients during COVID-19 pandemic: a call to action. CANCER CAUSES & CONTROL, v. 32, n. 1, . (18/23941-9)
REZENDE, LEANDRO F. M.; FERRARI, GERSON; BAHIA, LUCIANA RIBEIRO; ROSA, ROGER DOS SANTOS; MACHADO DA ROSA, MICHELLE QUARTI; DE SOUZA, ROMULO CRISTOVAO; LEE, DONG HOON; GIOVANNUCCI, EDWARD; ELUF-NETO, JOSE. Economic burden of colorectal and breast cancers attributable to lack of physical activity in Brazil. BMC PUBLIC HEALTH, v. 21, n. 1, . (18/23941-9)

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