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Effects of miR-29c on skeletal muscle plasticity: implications for the control of muscle mass

Grant number: 19/08996-4
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): June 01, 2019
Effective date (End): May 31, 2020
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Anselmo Sigari Moriscot
Grantee:William Jose da Silva
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/04090-0 - Identification and caracterization of mechanisms involved in skeletal muscle mass control and regeneration, AP.TEM


Good health and quality of life are closely related to the good performance of skeletal muscle tissue functions. For this, it is essential that the muscle can efficiently activate the processes that regulate the growth, regeneration, metabolism and adaptation of the mass in front of the demands of the environment. Under this latter aspect, muscle mass is mainly determined by the balance between synthesis and degradation of proteins. Several conditions lead to increased protein degradation, causing a reduction in mass and consequently inefficiency of muscle function (Atrophy), among which we can mention physiological states such as physical inactivity and aging, immobilization of fractured limbs, malnutrition and microgravity, in addition to pathological conditions such as the peripheral nerve section, sepsis, chronic treatment with corticosteroids, renal failure, AIDS and Cancer-induced Cachexia. For years our research group has been dedicated to elucidating mechanisms and identifying elements that can regulate skeletal muscle plasticity. During the development of subproject 3, we identified miR-29c as a potential hypertrophic agent, as well as inducing an increase in muscle mass and function, reducing expression and targeting MuRF1, one of the most expressed atrogenes in most atrophic conditions cited above. This postdoctoral project will proceed to subproject 3, further exploring the effects of hyperexpression of miR-29c on the effects on muscle metabolism and the mechanisms that lead to muscle hypertrophy, and these results have stimulated us to challenge the effects of miR-29c on some of these atrophic conditions, such as during food deprivation, denervation, immobilization, dexamethasone treatment and Cancer-induced Cachexia. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO ALVES, PAULA KETILLY; CRUZ, ANDRE; SILVA, WILLIAM J.; LABEIT, SIEGFRIED; MORISCOT, ANSELMO SIGARI. miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 13, p. 11-pg., . (21/05827-7, 19/08996-4, 18/24419-4, 15/04090-0, 17/09398-8, 21/03066-9)

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