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Effects of caloric restriction on mitochondrial Ca2+ transport in cardiac and skeletal muscles

Grant number: 19/05226-3
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2019
Effective date (End): May 31, 2024
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:Julian David Cualcialpud Serna
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID
Associated scholarship(s):22/12251-7 - Role of MICU2 in the regulation of mitochondrial functions and cell physiology, BE.EP.DD


We recently found that obese, ad libitum fed, rats and mice present lower mitochondrial Ca2+ uptake capacity in both the brain and liver when compared to lean, calorically-restricted animals. This was the first evidence that a dietary intervention can change mitochondrial Ca2+ transport properties. Ca2+ is a central metabolic regulator and, thus, diet-induced changes in mitochondrial Ca2+ transport may be both physiologically and pathologically relevant in other organs. This proposal aims to uncover possible changes in mitochondrial Ca2+ uptake in heart and skeletal muscle, and study physiological and pathological consequences of possible changes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERNA, JULIAN D. C.; AMARAL, ANDRESSA G.; CALDEIRA DA SILVA, CAMILLE C.; MUNHOZ, ANA C.; VILAS-BOAS, ELOISA A.; MENEZES-FILHO, SERGIO L.; KOWALTOWSKI, ALICIA J.. Regulation of kidney mitochondrial function by caloric restriction. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 323, n. 1, p. 15-pg., . (19/05226-3, 19/04233-6, 13/07937-8, 20/06970-5)
KAKIMOTO, PAMELA A.; SERNA, JULIAN DAVID C.; RAMOS, VITOR DE MIRANDA; ZORZANO, ANTONIO; KOWALTOWSKI, ALICIA J.. Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling. REDOX BIOLOGY, v. 45, . (19/18402-4, 13/07937-8, 15/25862-0, 19/05226-3)

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