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Circadianism and juvenile myoclonic epilepsy

Grant number: 18/23798-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2019
Effective date (End): June 30, 2020
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Kette Dualibi Ramos Valente
Grantee:Camila Koike
Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil


Juvenile myoclonic epilepsy has a well-known relation with sleep, since the onset of its seizures on awakening. In the initial reports on this generalized and genetically determined epileptic syndrome, there was a delayed sleep phase and complaints related to sleep quality. These observations were not confirmed by the following clinical studies which present controversial results. This study aims to determine the circadian pattern and sleep quality in patients with juvenile myoclonic epilepsy and the impact of these factors on social adequacy and quality of life. In order to do so, we intend to study 30 patients with juvenile myoclonic epilepsy through self-administered questionnaires for the Circadian Pattern (Morningness-Eveningness Questionnaire (MEQ), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). Quality of life will be assessed through the Quality of Life Questionnaire for patients with epilepsy - abbreviated version (QOLIE-31) and social functioning through the Social Adequacy Scale (EAS). Due to the importance of depressive symptoms, anxiety and the adverse effects of FAEs as confounding factors, these will also be evaluated and covariates. The data obtained with the application of questionnaires among patients with JME will be paired and compared to control groups.

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