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Production of secondary metabolites induced by UV-A light irradiated in fungi isolated from rosemary (Rosmarinus officinalis)

Grant number: 19/03677-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2019
Effective date (End): December 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Edson Rodrigues Filho
Grantee:Érika Bonatti
Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


Production of secondary metabolites induced by UV-A light irradiation in fungi isolated from Rosemary(Rosmarinus officinalis)". This proposed project aims to study the production of secondary metabolites from fungi isolated from Rosemary, induced by UV-A light, as well as their separation and characterization. Research on the influence of parameters related to the cultivation-medium for microorganisms growth is justified by the great applicability of natural products of fungi and bacteria on current biotechnology industry due to its bioactivities. These natural products have been used in pharmaceutical, chemistry, farming areas among others. The effect of light as one of interfering factors in the growth of fungi has been verified in the literature regarding identification of genes and proteins that are related to phtoreceiving capability of these organisms. In General biosynthetic genes occur regularly throughout kingdom Fungi. Thus, the study of the influence of different types of radiation over the fungi also brings the possibility of discovery of new secondary metabolites and a most complete elucidation of their metabolomic potential. The present work will involve the production of extracts and their analysis by liquid chromatography coupled to mass spectrometry (LC/MS) to identify the secondary metabolites produced by fungi, induced by UV-A radiation. Learning of organic chemical analysis and introduction to microbiology practices entered into a context of biotechnological potential, is the big gain foreseen for this step of scientific research initiation.

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